Disseminated Acanthamoeba sp infection in a dog

Department of Evolution, Ecology, and Organismal Biology, The Ohio State University, Columbus, Ohio, United States
Veterinary Parasitology (Impact Factor: 2.46). 04/2005; 128(3-4):183-7. DOI: 10.1016/j.vetpar.2004.11.022
Source: PubMed


Several species of free-living amoebae can cause encephalomyelitis in animals and humans. Disseminated acanthamoebiasis was diagnosed in pyogranulomatous lesions in brain, thyroid, pancreas, heart, lymph nodes, and kidney of a one-year-old dog. Acanthamoeba sp. was identified in canine tissues by conventional histology, by immunofluorescence, by cultivation of the parasite from the brain of the dog that had been stored at -70 degrees C for two months, and by PCR. The sequence obtained from the PCR product from the amoeba from the dog was compared to other sequences in the Acanthamoeba sp. ribosomal DNA database and was determined to be genotype T1, associated with other isolates of Acanthamoeba obtained from granulomatous amebic encephalitis infections in humans.

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Available from: Govinda Visvesvara, Feb 06, 2015
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    • "infection. Similar findings have been described in elsewhere (Ayers et al. 1972, Pearce et al. 1985, Bauer et al. 1993, Dubey et al. 2005, Reed et al. 2010, Kent et al. 2011). Systemic infection by Acanthamoeba spp. is rare in dogs and is generally associated with immunosuppressive conditions such as canine distemper (Reed et al. 2010), as seen in the three cases of this report, and corticosteroid therapy (Foreman et al. 2004). "
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