Primary non Hodgkin's lymphoma (NHL) of the cervix and vagina is uncommon; the incidence of uterine lymphoma is estimated to be less than 0.5% of all NHL. Patients regularly present with vaginal bleeding. The diagnosis is made on biopsy but this can be difficult on small samples which may not be representative of the lesion. Immunohistochemical analysis and often molecular techniques are required to confirm the diagnosis.
We report two cases of primary diffuse large B-cell lymphoma of the cervix. In the first case, the diagnosis could only be made on repeat biopsies. The second case presented as a cervical polyp.
Gynecologists should be aware of this rare clinical entity in order to apply the proper treatment.
"If the base is visualized, then cauterization should be performed to prevent further bleeding. All polyps that are removed should be sent to pathology to be evaluated for malignancy [52–54]. Furthermore, if there is concern for endometrial polyps, then the patient should be referred to operative hysteroscopy with possible dilation and curettage. "
[Show abstract][Hide abstract] ABSTRACT: Postcoital bleeding refers to spotting or bleeding that occurs after intercourse and is not related to menstruation. The prevalence of postcoital bleeding ranges from 0.7 to 9.0 percent of menstruating women. There are multiple etiologies for this common complaint in which most are benign such as cervicitis or cervical polyps. However, the most serious cause of postcoital bleeding is cervical cancer. There are currently no recommendations from governing bodies such as the American College of Obstetricians and Gynecologists on evaluating and treating women with postcoital bleeding. The purpose of this paper is to discuss the common causes of postcoital bleeding, the etiologies of postcoital bleeding, and the likelihood that malignancy is the underlying cause. After an extensive literature review, we compiled a paper illustrating the key concepts a practitioner should know when it comes to postcoital bleeding. Finally, this review will conclude with treatment options for women who are found to have an identifiable source for their bleeding and a discussion on the natural history of postcoital bleeding in women who are found to have no identifiable etiology on evaluation.
Obstetrics and Gynecology International 06/2014; 2014:192087. DOI:10.1155/2014/192087
[Show abstract][Hide abstract] ABSTRACT: Primary malignant lymphoma occurring in the uterine cervix is a rare event. We report a case of primary non-Hodgkin's lymphoma of the uterine cervix mimicking leiomyoma. The immunophenotype of the tumor and the differential diagnostic approach to this uncommon malignancy also are presented.
Pathology - Research and Practice 02/2006; 202(1):61-4. DOI:10.1016/j.prp.2005.10.009 · 1.40 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Primary uterine non-Hodgkin's lymphoma is a rare malignancy. We here describe 2 patients who presented with cervical growth, stage IE, diffuse large B cell histology. Both were treated with chemotherapy followed by involved field radiotherapy in 1 patient. They achieved complete clinical and radiological response. Data of 101 patients collected from the literature are reviewed.
American journal of obstetrics and gynecology 08/2006; 195(1):308-13. DOI:10.1016/j.ajog.2006.04.002 · 4.70 Impact Factor
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