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The use of clonidine for severe and intractable sleep problems in children with neurodevelopmental disorders - A case series

West London Mental Health NHS Trust, Londinium, England, United Kingdom
European Child & Adolescent Psychiatry (Impact Factor: 3.55). 03/2005; 14(1):34-40. DOI: 10.1007/s00787-005-0424-4
Source: PubMed

ABSTRACT This paper reports on the use of clonidine for the treatment of severe sleep problems associated with behavioural difficulties in children with neurodevelopmental disabilities. Data were obtained from reviewing the case notes of a series of six children with neurodevelopmental disorders of different nature and severity, presenting with problematic sleep. All children in this group showed maintained improvements in their sleep pattern following the use of clonidine with only mild side-effects reported.

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    • ", 2009 ) . Clonidine has also been used to treat sleep disturbances , which in some cases have been reported in up to one - third of patients with FXS ( Ingrassia and Turk , 2005 ; Kronk et al . , 2010 ) . "
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    • "Schnoes et al. [33] reported that clonidine was ranked second by pediatricians for treatment of sleep disorders, including sleep onset, sleep schedule, nighttime awakening, early morning awakening, and parasomnias. Ingrassia and Turk [34] found clonidine to be effective in treating severe and intractable sleep problems in children with neurodevelopmental disorders . Clonidine was reported to improve nocturnal hypoxemia and obstructive sleep apnea, possibly due to suppression of REM sleep[35]. "
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