Article

Erythrocyte Cu/Zn superoxide dismutase activity in preterm infants with and without bronchopulmonary dysplasia.

Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan.
Biology of the Neonate (impact factor: 1.9). 02/2005; 88(1):35-41. DOI:10.1159/000084456 pp.35-41
Source: PubMed

ABSTRACT Erythrocyte Cu/Zn superoxide dismutase is believed to play a major role as a first-line antioxidant defense. Studies have reported varying results from measures of superoxide dismutase activity in cord blood samples from neonates.
The study goal was to assess enzyme activity for preterm infants representing a range of gestational ages during the 1st week of life. Clinical data were obtained and correlations with superoxide dismutase activity were examined.
We collected blood samples from umbilical arterial lines or the radial artery of 44 preterm infants (gestational age range 25-30 weeks) on days 1, 3, and 6 after delivery and evaluated erythrocyte Cu/Zn superoxide dismutase activity.
There was no correlation between enzyme activity and gestational age or birth weight. Superoxide dismutase activity gradually increased in preterm infants with bronchopulmonary dysplasia on days 3 and 6, with levels significantly higher than those of preterm infants without bronchopulmonary dysplasia on day 6. We found that packed red cell transfusion did not affect erythrocyte superoxide dismutase activity in either group. However, higher cumulative oxygen administration was noted in preterm infants with bronchopulmonary dysplasia.
Higher cumulative oxygen administration may be one factor that upregulates the activity of erythrocyte superoxide dismutase.

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Keywords

1st week
 
44 preterm infants
 
birth weight
 
blood samples
 
Clinical data
 
cord blood samples
 
days 3
 
enzyme activity
 
Erythrocyte Cu/Zn superoxide dismutase
 
erythrocyte Cu/Zn superoxide dismutase activity
 
erythrocyte superoxide dismutase
 
erythrocyte superoxide dismutase activity
 
first-line antioxidant defense
 
gestational age range 25-30 weeks
 
higher cumulative oxygen administration
 
packed red cell transfusion
 
radial artery
 
superoxide dismutase activity
 
umbilical arterial lines
 
varying results
 

Ren-Huei Fu