Effect of topical treatment with skin barrier-enhancing emollients on nosocomial infections in preterm infants in Bangladesh: a randomised controlled trial
ABSTRACT Infections and complications of prematurity are main causes of neonatal mortality. Very low birthweight premature infants have compromised skin barrier function, and are at especially high risk for serious infections and mortality. Our aim was to ascertain whether topical application of emollients to enhance skin barrier function would prevent nosocomial infections in this population.
We randomly assigned infants born before week 33 of gestation after admission to Dhaka Shishu Hospital, Bangladesh, to daily massage with sunflower seed oil (n=159) or Aquaphor (petrolatum, mineral oil, mineral wax, lanolin alcohol; n=157). We then compared incidence of nosocomial infections among infants in these two groups with an untreated control group (n=181) by an intention-to-treat analysis.
20 patients in the control group, and 22 in each of the treatment groups left the hospital early, but were included in the final analysis. Overall, infants treated with sunflower seed oil were 41% less likely to develop nosocomial infections than controls (adjusted incidence rate ratio [IRR] 0.59, 95% CI 0.37-0.96, p=0.032). Aquaphor did not significantly reduce the risk of infection (0.60, 0.35-1.03, p=0.065). No adverse events were seen.
Our findings confirm that skin application of sunflower seed oil provides protection against nosocomial infections in preterm very low birthweight infants. The low cost, availability, simplicity, and effect of treatment make it an important intervention for very low birthweight infants admitted to hospital in developing countries.
Full-textDOI: · Available from: Nawshad Ahmed, Jun 02, 2015
SourceAvailable from: Baba Usman Ahmadu[Show abstract] [Hide abstract]
ABSTRACT: Background: Some researchers have suggested that when Naegle's rule (NR) and Dubowitz score (DS) are combined, it could out-perform obstetric ultrasound scan (USS). Others still believe that obstetric USS alone is still effective relative to the combination of NR rule and DS in assessing the gestational age (GA) of babies. Objectives: To determine and compare the GA of babies using obstetric USS, NR and DS; and to provide relevant public health information on obstetric USS in the 21st century. Methods: Subjects were selected using systematic ran-dom sampling and the GA of babies was deter-mined using obstetric USS, NR, and DS. Statis-tical package for social science (SPSS) statisti-cal software version 16, Illinois, Chicago USA was used for all data analysis. Results: Eighty-five mother-baby pairs were studied. Forty-four babies (52%) were males and 41 (48%) females. Sixty four (75%) were term with a mean (SD) BW of 3.02 (0.59) at 95%CI (2.89 -3.14) kg. The over-all mean GA of the babies was 38.49 (2.89) at 95%CI (38.14 -38.85) weeks. The mean GA using obstetric USS, NR and DS were 38., but comparison of these means was not significant (p = 0.256). Combined mean GA by NR and DS was 38.46 (3.26) at 95%CI (37.96 -38.95). Comparing this mean with mean GA ob-tained by obstetric USS was also not significant (p = 0.885). Conclusion: The GA assessments by Obstetric USS, NR and DS were all reliable, and Obstetric USS performed effectively relative to combined NR and DS.Natural Science 07/2013; 599823826(38):32-3514. DOI:10.4236/ns.2013.58A2005
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ABSTRACT: This paper aims to summarize the outcomes of in vivo and in vitro studies relating to cosmeceutical and phytopharmaceutical potency of sunflower seed oil based on the epidemiological evidence published in the last 13 years. Study design of the reviewed literature included 25 selected scientific articles, as follows: randomized human studies (11), animal studies (6), reviews (5), and in vitro studies (3). Topical applied product consisted in raw sunflower seed oil, mixtures with other oils or herbs, and trade cosmetic or medicinal products. Fatty acids from this vegetable oil were shown to alleviate symptoms associated with skin sensitivity and inflammatory skin disorders, as well as to protect skin from photodamage and photoaging. Health benefits of sunflower oil were also found when applying on gingival, respectively on gastric mucosa. In conclusion, topical administration has proven certain positive skin effects but further research may be warranted in order to design more potent and safe phytopharmaceuticals.