Ossifying fibromyxoid tumor of the skin: A report of 2 cases with light microscopic, immunohistochemical, and electron microscopic characterization

Department of Dermatology, University of Southern California-Keck School of Medicine, Los Angeles, California, USA.
Journal of the American Academy of Dermatology (Impact Factor: 4.45). 05/2005; 52(4):644-7. DOI: 10.1016/j.jaad.2004.11.053
Source: PubMed


Ossifying fibromyxoid tumor is a rare fibro-osseous neoplasm occurring predominantly in the subcutaneous tissue and/or skeletal muscle of the extremities. The immunohistochemical and ultrastructural studies in reported cases favor neural or Schwannian origin. To date, ossifying fibromyxoid tumor presenting as a primary skin tumor has not been described in the literature. Two cases of primary cutaneous ossifying fibromyxoid tumor with light microscopic, immunohistochemical, and ultrastructural characterization are presented. Our observations also support neural differentiation of these tumors.

7 Reads
  • [Show abstract] [Hide abstract]
    ABSTRACT: A DC-DC converter and a DC-AC inverter are under development for More Electric Aircraft (MEA) use. They are both highly compact and are designed to operate from 270 Vdc input power and produce output power that meets requirements for fighter aircraft, including compliance with MIL-STD-704E and MIL-STD-461D guidelines. Both units are designed to be cooled with Poly Alpha Olefin (PAO) at 30°C maximum inlet temperature and to operate for at least 30 s after a loss of coolant flow before shutting down. Both units are designed to withstand 20 Gs shock loadings and random vibration loadings up to 0.04 G<sub>rms</sub> <sup>2</sup>/Hz for the DC-DC converter and 0.36 G<sub>rms</sub><sup>2 </sup>/Hz for the DC-AC inverter. The reliability goal is 25000 hour mean time between failures (MTBF). Both units incorporate under/over voltage, short circuit, and over temperature protection. The DC-AC inverter also has over/under frequency, DC content, waveform distortion, and zero voltage content protection. The DC-DC converter provides 5.6 kW at 29±0.5 Vdc with an efficiency of 90%. It weighs 8.9 lb and is 5" long by 5" wide by 5.5" high (138 in<sup>3</sup>). The DC-AC inverter provides 8 kVA of three phase power at (115±1.5)/200 Vac and 400 Hz with an efficiency of 87%. It weighs 18.2 lbs and is 11.5" long by 5" wide by 5.5" high (316 in<sup>3</sup>). The paper describes the design of both units and the resulting performance. The results of tests on both units are summarized
    Energy Conversion Engineering Conference, 1996. IECEC 96. Proceedings of the 31st Intersociety; 09/1996
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Ossifying fibromyxoid tumor of soft parts (OFMT) is a rare mesenchymal neoplasm of intermediate malignant potential. The tumor most commonly occurs on the extremities with a male predominance. We present an unusual case of OFMT occurring as a cystic lesion on the scalp of a female. A 67-year-old woman presented with a 6-year history of a well demarcated cystic scalp mass. Physical examination revealed a slightly movable, multilobular mass of the left parietal scalp which was subsequently excised. Histological evaluation revealed an OFMT comprised of bland, small cells and a thick collagenous capsule containing an incomplete rim of lamellar bone. OFMT is an unusual tumor which can usually be considered as having an intermediate risk of malignancy. It generally occurs in the extremities with a male predominance. The clinical differential for a cystic mass on the scalp is broadened by this unusual case of an OFMT.
    Journal of Cutaneous Pathology 09/2006; 33(8):569-72. DOI:10.1111/j.1600-0560.2006.00444.x · 1.58 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Ossifying fibromyxoid tumor (OFMT) is an uncommon neoplasm occurring predominantly in the deep soft tissues of the trunk and proximal extremities. The lineage of this rare tumor to date is still uncertain. We present a case of a subcutaneous OFMT that recurred 8 years after initial resection. The histological findings of the primary and recurrent lesions are compared along with the histologic features possibly associated with aggressiveness. Dermatopathologists should consider OFMT in the differential diagnosis of subcutaneous neoplasms with a myxoid matrix.
    Journal of Cutaneous Pathology 12/2006; 33(11):749-53. DOI:10.1111/j.1600-0560.2006.00540.x · 1.58 Impact Factor
Show more