Article

DNA photocleavage and biological activity of a pyrene dihydrodioxin.

Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA.
Bioorganic & Medicinal Chemistry Letters (impact factor: 2.55). 05/2005; 15(8):2173-6. DOI:10.1016/j.bmcl.2005.02.003 pp.2173-6
Source: PubMed

ABSTRACT A pyrene dihydrodioxin has been synthesized, shown to bind to duplex DNA by intercalation, and cleave the phiX 174 supercoiled plasmid upon irradiation with UV light. This compound also exhibits cytotoxic activity at the micromolar range in a number of human cancer cell lines.

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Keywords

bind
 
duplex DNA
 
human cancer cell lines
 
micromolar range
 
phiX 174 supercoiled plasmid
 

Eric T Mack