Article

6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists.

Schering-Plough Research Institute, Chemical Research, 2015 Galloping Hill Road, MS 2545, Kenilworth, NJ 07033, USA.
Bioorganic & Medicinal Chemistry Letters (impact factor: 2.55). 05/2005; 15(8):2119-22. DOI:10.1016/j.bmcl.2005.02.031 pp.2119-22
Source: PubMed

ABSTRACT Structure-activity relationships have been investigated through substitutions at the 9-position of the 2-amino-6-(2-furanyl) purine (5) to identify novel and selective A(2A) adenosine receptor antagonists. Several potent and selective antagonists were identified. In particular, compounds 20, 25, and 26 show very high affinity with excellent selectivity.

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Keywords

compounds 20
 
excellent selectivity
 
selective A(2A)
 
selective antagonists
 
substitutions
 

Eugenia Kiselgof