6-(2-Furanyl)-9H-purin-2-amine derivatives as A(2A) adenosine antagonists

Schering-Plough Research Institute, Chemical Research, 2015 Galloping Hill Road, MS 2545, Kenilworth, NJ 07033, USA.
Bioorganic & Medicinal Chemistry Letters (Impact Factor: 2.42). 05/2005; 15(8):2119-22. DOI: 10.1016/j.bmcl.2005.02.031
Source: PubMed


Structure-activity relationships have been investigated through substitutions at the 9-position of the 2-amino-6-(2-furanyl) purine (5) to identify novel and selective A(2A) adenosine receptor antagonists. Several potent and selective antagonists were identified. In particular, compounds 20, 25, and 26 show very high affinity with excellent selectivity.

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