Synthesis and in vivo Antihyperglycemic Activity of 5-(1H-Pyrazol-3-yl)methyl-1H-tetrazoles.

Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226001, India.
Bioorganic & Medicinal Chemistry Letters (Impact Factor: 2.42). 05/2005; 15(8):2115-7. DOI: 10.1016/j.bmcl.2005.02.060
Source: PubMed


A series of 5-[(5-aryl-1H-pyrazol-3-yl)methyl]-1H-tetrazoles 3a-h have been synthesized and evaluated for their in vivo antihyperglycemic activity. Some of the synthesized compounds have shown significant glucose lowering activity in male Sprague-Dawley rats in sucrose loaded model. These compounds were also evaluated for their peroxisome proliferator activated receptor gamma agonistic property, but none of them displayed any significant activity.

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