Synthesis and in vivo Antihyperglycemic Activity of 5-(1H-Pyrazol-3-yl)methyl-1H-tetrazoles.
ABSTRACT A series of 5-[(5-aryl-1H-pyrazol-3-yl)methyl]-1H-tetrazoles 3a-h have been synthesized and evaluated for their in vivo antihyperglycemic activity. Some of the synthesized compounds have shown significant glucose lowering activity in male Sprague-Dawley rats in sucrose loaded model. These compounds were also evaluated for their peroxisome proliferator activated receptor gamma agonistic property, but none of them displayed any significant activity.
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- "Tetrazoles are big-league of heterocyclic compounds with assorted biological applications and are non-classical isosteric replacement of the carboxylic acid functionality  in drugs. Tetrazole moiety containing compounds have considerable medicinal applications as anti-inflammatory , anti-allergic , iNOS-inhibitor , and anti-diabetic  agents. Losartan (Fig. 1)  is one of the best examples for pharmacologically active 5-substituted 1 H-tetrazole derivatives, useful as a drug against hypertension. "
ABSTRACT: A strategy for the synthesis of 5-substituted 1H-tetrazoles from various (E)-aldoximes and sodium azide was adopted using copper ferrite nanoparticles as a reusable catalyst.Letters in Organic Chemistry 09/2014; 11(6):440-445. DOI:10.2174/1570178611666140210213157 · 0.65 Impact Factor
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ABSTRACT: Data on drugs of the tetrazole series published over the last decade are reviewed. The use of tetrazoles as isosteric substituents of various functional groups is examined.Chemistry of Heterocyclic Compounds 01/2007; 43(1):1-9. DOI:10.1007/s10593-007-0001-5 · 0.70 Impact Factor
- ChemInform 08/2005; 36(33). DOI:10.1002/chin.200533140