24-Hour Intraocular Pressures with Brimonidine Purite versus Dorzolamide Added to Latanoprost in Primary Open-Angle Glaucoma Subjects

University of South Carolina, Columbia, South Carolina, United States
Ophthalmology (Impact Factor: 6.14). 05/2005; 112(4):603-8. DOI: 10.1016/j.ophtha.2004.11.032
Source: PubMed


To evaluate the 24-hour efficacy of brimonidine purite versus dorzolamide, each added to latanoprost.
Double-masked, 2-center, prospective, crossover comparison.
Primary open-angle glaucoma (POAG) subjects.
Subjects were randomized to brimonidine purite or dorzolamide, each given twice daily, for the first 6-week treatment period after a 6-week latanoprost run-in. Subjects began the opposite treatment for the second 6-week period after a 6-week latanoprost-only treatment between periods. Intraocular pressure (IOP) was measured at 8 am, 12 pm, 4 pm, 8 pm, 12 am, 4 am, and 8 am at each baseline and at the end of each treatment period. This study provided an 80% power that a 1.5-mmHg difference could be excluded between groups if 27 subjects completed the study. A standard deviation (SD) of 2.8 mmHg was assumed.
Twenty-four-hour efficacy of intraocular pressures of brimonidine purite versus dorzolamide, each added to latanoprost.
In 31 completed subjects, the baseline mean diurnal 24-hour IOP (+/- SD) was 19.0+/-1.7 mmHg for brimonidine purite and 19.0+/-1.6 mmHg for dorzolamide (P = 0.52). The 8 am IOP after 6 weeks of therapy was 18.4+/-2.1 mmHg for brimonidine purite and 18.9+/-1.9 mmHg for dorzolamide (P = 0.40). The mean diurnal IOP was 16.9+/-1.5 mmHg for brimonidine purite and 16.8+/-1.5 mmHg for dorzolamide (P = 0.66). Dorzolamide caused a more bitter taste (P = 0.01) than brimonidine purite.
This study suggests that brimonidine purite and dorzolamide, added to latanoprost, have similar efficacy and safety in POAG or ocular hypertensive subjects.

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Available from: Constantinos H Karabatsas, Sep 29, 2014
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    • "Several randomized controlled clinical studies in patients with glaucoma or OHT subsequently confirmed that brimonidine provides significant additional mean decreases in IOP when added to ongoing beta-blocker therapy (Simmons 2001; Simmons and Earl 2002; Sall et al 2003; Solish et al 2004). Other randomized controlled trials showed that brimonidine effectively reduces IOP when used adjunctively with a prostaglandin analogue (bimatoprost or latanoprost) (Netland et al 2003; Zabriskie and Netland 2003; Konstas et al 2005). "
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