Oxygen JNKies: phosphatases overdose on ROS.

The Ben May Institute for Cancer Research, The University of Chicago, 924 East 57th Street, Chicago, Illinois 60637, USA.
Developmental Cell (Impact Factor: 9.71). 05/2005; 8(4):452-4. DOI: 10.1016/j.devcel.2005.03.005
Source: PubMed


Proinflammatory cytokine TNFalpha triggers cell death by inducing reactive oxygen species (ROS). These then inflict cytotoxicity through downstream activation of the JNK MAPK cascade. Yet the mechanisms by which ROS trigger JNK signaling have remained elusive. In a recent issue of Cell, Kamata et al. now provide one such mechanism.

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