"Frontal fibrosing alopecia (FFA), first described in 1994 (Kossard, 1994), is a primary scarring alopecia that is considered a clinical variant of lichen planopilaris (Kossard et al., 1997). It occurs mainly in postmenopausal women (Kossard, 1994), although premenopausal women (Moreno-Ramirez and Camacho Martinez, 2005; Faulkner et al., 2002; Banka et al., 2014; Vañó-Galván et al., 2014) and men (Kossard and Shiell, 2005; Nusbaum and Nusbaum, 2010; Stockmeier et al., 2002; Dlova and Goh, 2013; Ramaswamy et al., 2012) may also be affected. Most data on FFA comes from studies and case reports including a majority of white and Asian patients. "
[Show abstract][Hide abstract] ABSTRACT: Skin of color comprises a diverse and expanding population of individuals. In particular, women of color represent an increasing subset of patients who frequently seek dermatologic care. Acne, melasma, and alopecia are among the most common skin disorders seen in this patient population. Understanding the differences in the basic science of skin and hair is imperative in addressing their unique needs. Despite the paucity of conclusive data on racial and ethnic differences in skin of color, certain biologic differences do exist, which affect the disease presentations of several cutaneous disorders in pigmented skin. While the overall pathogenesis and treatments for acne in women of color are similar to Caucasian men and women, individuals with darker skin types present more frequently with dyschromias from acne, which can be difficult to manage. Melasma is an acquired pigmentary disorder seen commonly in women with darker skin types and is strongly associated with ultraviolet (UV) radiation, genetic factors, and hormonal influences. Lastly, certain hair care practices and hairstyles are unique among women of African descent, which may contribute to specific types of hair loss seen in this population, such as traction alopecia, trichorrhexis nodosa and central centrifugal cicatricial alopecia (CCCA).
"Frontal fibrosing alopecia (FFA) in an entity characterized by the recession of the frontotemporal hairline (FTHL) with alopecic scarring changes, usually accompanied by alopecia in other non-scalp locations. Initially defined as a disease appearing only in postmenopausal women, no hormonal status association was later proven. However, the rest of FFA clinical manifestations such as axillar or eyebrow alopecia, lichen planopilaris, or pruritus appear in a variable frequency, except for the mentioned recession of the hairline present in all patients. "
[Show abstract][Hide abstract] ABSTRACT: Frontal fibrosing alopecia (FFA) in an entity characterized by the recession of the frontotemporal hairline (FTHL) with alopecic scarring change. In recent years there are numerous articles discussing the usefulness of dermoscopy for the clinical diagnosis of different types of scarring alopecia.
We value 79 patients diagnosed with FFA, evaluating some trichoscopical findings described as typical for FFA: Absence of follicular opening, follicular hyperkeratosis, follicular plugs and erythema.
In a population of 79 women, 100% showed no follicular opening, 72.1% follicular hyperkeratosis, 66.3% perifollicular erythema and 44.8% follicular plugs. Thus, 100% of patients had at least one of the dermoscopic elements described as suggestive of FFA, 53% two of them, 45% three and 27%, all those elements. Perifollicular erythema was present in 95% of cases in which the disease was active.
We consider that the presence of perifollicular erythema will be a direct marker of FFA activity.
International Journal of Trichology 07/2013; 5(3):151-3. DOI:10.4103/0974-7753.125616
[Show abstract][Hide abstract] ABSTRACT: The in vitro interaction between the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and cytoskeletal elements is well documented. To verify this association within cells, the intracellular distribution of GAPDH under various metabolic conditions has been investigated in immunostained cells or cells expressing GAPDH as a GFP fusion protein. GAPDH was homogeneously distributed in the cytoplasm and no interaction of GAPDH with cytoskeletal elements, neither with microfilaments nor microtubules or intermediate filaments, was detectable. In living cells expressing GFP-GAPDH, stress fibres were excluded from the fluorescence. In contrast to proliferating cells, the cytoplasmic GAPDH of serum-depleted cells was not homogeneously distributed, but colocalised with stress fibres. The mechanism for stimulating this actin-binding affinity was independent of the NO-signalling pathway. The results support the idea of a specialised function for the interaction of GAPDH and cytoskeletal elements, rather than a general function, as e.g. microcompartmentalization of glycolytic enzymes.
Cell Biology International 02/2002; 26(2):155-64. DOI:10.1006/cbir.2001.0819 · 1.93 Impact Factor
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