Omega-3 fatty acids for the prevention of postpartum depression: Negative data from a preliminary, open-label pilot study
ABSTRACT Based on the putative relationship between depleted omega-3 fatty acids and postpartum depression, we initiated an open-label pilot study of omega-3 fatty acid supplementation with the aim of preventing postpartum depression. Euthymic pregnant females with a past history of depression in the postpartum period were started on 2960 mg of fish oil (1.4:1 eicosapentaenoic acid:docosahexaenoic acid) per day between the 34th to 36th week of pregnancy and assessed through 12 weeks postpartum. Four of seven participants had a depressive episode during the study period. No participants withdrew from the study due to adverse events. This preliminary, small, open-label pilot study failed to show promising results for the use of omega-3 fatty acid monotherapy beginning at 34 to 36 weeks gestation for the prevention of postpartum depression in patients with a prior postpartum depression history. Controlled studies are lacking.
SourceAvailable from: Dorothy SitPsychiatric Annals 07/2005; 35(7):577-584. DOI:10.3928/0048-5713-20050701-15 · 0.71 Impact Factor
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ABSTRACT: Omega-3 fatty acids participated in the first coherent experimental demonstration of the effect of dietary substances (nutrients) on the structure and function of the brain. Experiments were first of all carried out on ex-vivo cultured brain cells, then on in vivo brain cells, finally on physiochemical, biochemical, physiological, neurosensory, and behavioural parameters. These findings indicated that the nature of polyunsaturated fatty acids (in particular omega-3) present in formula milks for infants (both premature and term) determines the visual, cerebral, and intellectual abilities, as described in a recent review in OCL . In view of the high omega-3 polyunsaturated fatty acid content of the brain, it is evident that these fats are involved in brain biochemistry, physiology and functionning; and thus in some neuropsychiatric diseases and in the cognitive decline of ageing. Though omega-3 fatty acids appear effective in the prevention of stress, their role as regulator of mood and libido is a matter for discussion pending experimental proof in animal and human models. Dietary omega-3 fatty acids could play a role in the prevention of some disorders including depression, as well as in dementia, particularly Alzheimer's disease. Their direct role in major depression and bipolar disorder (manic-depressive disease) and schizophrenia is not yet established. Their deficiency can prevent the renewal of membranes, and thus accelerate cerebral ageing; nonetheless, the respective roles of the vascular component on one hand (where the omega-3's are active) and the cerebral parenchyma itself on the other, have not yet been clearly resolved. The role of omega-3 in certain diseases such as dyslexia and autism is suggested. The role of omega-3 in certain diseases such as dyslexia, autism, and schizophrenia seems to suggest a problem of diet. Indeed, the insufficient dietary supply of omega-3 fatty acids in today's French diet raises the problem of how to correct dietary habits so that the consumer will select foods that are genuinely rich in omega-3/the omega-3 family; mainly rapeseed and walnut oils on one hand and fatty fish on the other.OCL - Oleagineux Corps Gras Lipides 07/2004; 11(4-5). DOI:10.1051/ocl.2004.0362
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ABSTRACT: The World Health Organization estimates that major depression affects about 350 million people all over the world and reports this disorder as the major contributor to the global burden of diseases. Despite the well-defined symptomatology, major depression is a heterogeneous psychiatric disorder whose pathophysiology is not clearly established. Although several treatments are available, most depressed patients do not achieve the complete remission of symptoms. Factors linked to the persistence of the disorder have been investigated, particularly those related to the way of life. Moreover, it has been suggested that nutritional aspects may influence its development. Among them, a diet rich in ω-3 has been associated with a reduced risk of major depression, although its deficiency is associated with depressive disorders.Acta Neuropsychiatrica 06/2014; 26(3):178-85. DOI:10.1017/neu.2013.52 · 0.64 Impact Factor