Lack of asymmetrical transfer for linguistic stimuli in schizophrenia: An ERP study

School of Psychology, Trinity College Dublin, Dublin, Leinster, Ireland
Clinical Neurophysiology (Impact Factor: 3.1). 06/2005; 116(5):1019-27. DOI: 10.1016/j.clinph.2004.12.008
Source: PubMed


To assess the mechanisms underlying lack of speeded information transfer asymmetry (faster right to left) for verbal information in schizophrenia.
Interhemispheric transfer times (IHTT) between the hemispheres were assessed using a lateralized lexical-decision task in males with schizophrenia (N = 12) and matched controls (N = 12). Words were presented to the left visual field (LVF), right visual field (RVF), or bilaterally (BVF) while 128-channel EEG was recorded continuously. A direct measure of IHTT in each direction was obtained by comparing the latencies of the N160 evoked potential (EP) component in the hemispheres contralateral and ipsilateral to stimulation.
Controls showed faster information transfer from the right to left hemisphere (R-to-L) for linguistic stimuli. The two groups did not differ for IHTTs L-to-R. Lack of IHTT asymmetry in the schizophrenia groups was associated with an overall concomitant decrease in the amplitude of the N160 in the right hemisphere.
Differences in IHTT asymmetry may be attributed to lack of right hemisphere activation and not callosal dysfunction as has been previously suggested.
It is suggested that a relative excess of myelinated axons in the right hemisphere speeds IHTT faster R-to-L, findings are discussed with reference to differences in right hemisphere white matter connectivity in schizophrenia.

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    • "Numerous studies of IHTT have shown that neural information travels more quickly from the right hemisphere of the brain to the left hemisphere, than from left hemisphere of the brain to right hemisphere in neurologically healthy adults (e.g., [29,30,31,32]). Miller [33] has proposed that the right hemisphere of the brain contains a greater number of heavily myelinated axons than the left hemisphere, enhancing its performance in fast parallel processes. Studies combining electrophysiology and anatomical imaging have shown that the speed of hemispheric transfer is inversely correlated with fractional anisotropic values in the posterior corpus callosum [34], suggesting that greater callosal integrity may result in quicker hemispheric transfer. "
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    ABSTRACT: Increasing behavioural evidence suggests that expert video game players (VGPs) show enhanced visual attention and visuospatial abilities, but what underlies these enhancements remains unclear. We administered the Poffenberger paradigm with concurrent electroencephalogram (EEG) recording to assess occipital N1 latencies and interhemispheric transfer time (IHTT) in expert VGPs. Participants comprised 15 right-handed male expert VGPs and 16 non-VGP controls matched for age, handedness, IQ and years of education. Expert VGPs began playing before age 10, had a minimum 8 years experience, and maintained playtime of at least 20 hours per week over the last 6 months. Non-VGPs had little-to-no game play experience (maximum 1.5 years). Participants responded to checkerboard stimuli presented to the left and right visual fields while 128-channel EEG was recorded. Expert VGPs responded significantly more quickly than non-VGPs. Expert VGPs also had significantly earlier occipital N1s in direct visual pathways (the hemisphere contralateral to the visual field in which the stimulus was presented). IHTT was calculated by comparing the latencies of occipital N1 components between hemispheres. No significant between-group differences in electrophysiological estimates of IHTT were found. Shorter N1 latencies may enable expert VGPs to discriminate attended visual stimuli significantly earlier than non-VGPs and contribute to faster responding in visual tasks. As successful video-game play requires precise, time pressured, bimanual motor movements in response to complex visual stimuli, which in this sample began during early childhood, these differences may reflect the experience and training involved during the development of video-game expertise, but training studies are needed to test this prediction.
    PLoS ONE 09/2013; 8(9):e75231. DOI:10.1371/journal.pone.0075231 · 3.23 Impact Factor
    • "To correct bad channels, spline interpolation was performed from good channels. Consistent with prior ERP IHTT research (Barnett and Kirk 2005; Iwabuchi and Kirk 2009; Patson et al. 2007; Steger et al. 2001), data were average rereferenced. Polar average reference effect correction was also implanted to correct for inadequate surface sampling (Junghöfer et al. 1999). "
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    ABSTRACT: Little is known about the functional impact of putative deficits in white-matter connectivity across the corpus callosum (CC) in individuals with autism spectrum disorders (ASDs). We utilized the temporal sensitivity of event-related potentials to examine the interhemispheric transfer time (IHTT) of basic visual information across the CC in youth with high-functioning ASD relative to healthy controls. We conducted two experiments: a visual letter matching experiment (n = 46) and a visual picture matching experiment, (n = 48) and utilized both electrophysiological (N1 and P1 amplitudes and latencies) and behavioral [response times (RTs), error rates] indices of IHTT. There were no significant group differences on either experiment for RTs, error rates, or N1 and P1 latencies, suggesting that on basic tasks the timing of information flow across the CC may not be altered in high functioning ASD.
    Journal of Autism and Developmental Disorders 07/2013; 45(2). DOI:10.1007/s10803-013-1895-7 · 3.06 Impact Factor
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    • "Endrass et al., 2002), and that transfer times would be greatest in the AH group. Word stimuli activate a large cortical network, and there is evidence from previous studies (Barnett and Kirk, 2005; Endrass et al., 2002; Rockstroh et al., 2001) that evoked responses for verbal stimuli show important interhemispheric transfer differences from those evoked in response to tones in patients with psychosis. Following Crow's (1998) hypothesis that cerebral lateralization is altered in schizophrenia, and that language processing is consequently affected in this group of patients, we further hypothesised that differences in interhemispheric transfer time may be specific to word stimuli. "
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    ABSTRACT: Central auditory processing in schizophrenia patients with a history of auditory hallucinations has been reported to be impaired, and abnormalities of interhemispheric transfer have been implicated in these patients. This study examined interhemispheric functional connectivity between auditory cortical regions, using temporal information obtained from latency measures of the auditory N1 evoked potential. Interhemispheric Transfer Times (IHTTs) were compared across 3 subject groups: schizophrenia patients who had experienced auditory hallucinations, schizophrenia patients without a history of auditory hallucinations, and normal controls. Pure tones and single-syllable words were presented monaurally to each ear, while EEG was recorded continuously. IHTT was calculated for each stimulus type by comparing the latencies of the auditory N1 evoked potential recorded contralaterally and ipsilaterally to the ear of stimulation. The IHTTs for pure tones did not differ between groups. For word stimuli, the IHTT was significantly different across the 3 groups: the IHTT was close to zero in normal controls, was highest in the AH group, and was negative (shorter latencies ipsilaterally) in the nonAH group. Differences in IHTTs may be attributed to transcallosal dysfunction in the AH group, but altered or reversed cerebral lateralization in nonAH participants is also possible.
    International journal of psychophysiology: official journal of the International Organization of Psychophysiology 02/2012; 84(2):130-9. DOI:10.1016/j.ijpsycho.2012.01.020 · 2.88 Impact Factor
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