“Consent Forms and the Therapeutic Misconception: The Example of Gene Transfer Research,”
University of North Carolina at Chapel Hill, USA.IRB Ethics and Human Research 01/2005; 27(1):1-8. DOI: 10.2307/3563865
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- "That physicians/investigators themselves incorrectly conceive clinical trials from a therapeutic perspective also exacerbates the therapeutic misconception . Although the therapeutic misconception matters ethically for a variety of reasons , failure to distinguish the aims of research participation from those of medical treatment can seriously undermine informed consent  . If subjects misunderstand the goal of research, they are likely to underestimate risks or overestimate benefits. "
ABSTRACT: First-in-human clinical trials of innovative medical procedures, such as cell transplantation for Parkinson's disease, present a variety of ethical challenges. In an era of rapidly developing stem cell technologies likely to be translated into clinical trials over the next few years, it is critical that ethical concerns be fully considered. One important undertaking is ensuring that research participants give free and truly informed consent. This will necessitate adequate disclosure of risks and benefits at a time when these are incompletely defined; ensuring understanding of a complex research protocol when there is significant possibility of therapeutic misconception; and careful determination of capacity for informed consent in patients with a neurodegenerative disorder that is known to affect cognition. Here we call attention to the ethical issues that researchers conducting these types of trials will face when trying to obtain a genuinely informed consent, and we suggest possible solutions. Copyright © 2015. Published by Elsevier Ltd.Parkinsonism & Related Disorders 05/2015; 21(8). DOI:10.1016/j.parkreldis.2015.05.011 · 3.97 Impact Factor
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- "The significance of the King et al. (2005) study is heightened by the reality that the participants all suffered from diseases such as cancer and HIV. King and her colleagues found that individuals struggling with these incurable diseases were often misled about the difference between research, which is intended to produce knowledge, and therapeutic treatment, which is intended to produce a cure or alleviate symptoms. "
ABSTRACT: The mapping of the human genome and scientific discoveries regarding genetic contribu - tions to disease hold great promise for the prevention and treatment of an array of conditions. Social workers and other professionals must keep abreast of these developments and the ethi - cal dimensions of such progress. Familiar ethical provisions such as confidentiality, informed consent, self-determination, and social justice take on new meaning in light of innovations in genetic science. This article reviews ethical issues and practice implications emerging from advances in genetics knowledge, and it suggests mechanisms for continuing professional devel - opment and involvement in this important area. ETHICSFamilies in society: the journal of contemporary human services 10/2008; 89(4). DOI:10.1606/1044-3894.3820 · 0.29 Impact Factor
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ABSTRACT: To date, ethics discussions about stem cell research overwhelmingly have centered on the morality and acceptability of using human embryonic stem cells. Governments in many jurisdictions have now answered these “first-level questions” and many have now begun to address ethical issues related to the donation of cells, gametes, or embryos for research. In this commentary, we move beyond these ethical concerns to discuss new themes that scientists on the forefront of NRM development anticipate, providing a preliminary framework for further discussion between scientists and ethicists. Fostering strong partnerships between neuroscientists and ethicists that operate and collaborate within this evolving framework will maximize the translation of NRM discoveries on the brain into cures that are safe and address the needs of science and society.Neuroethics 04/2008; 2(1):13-20. DOI:10.1007/s12152-008-9025-5 · 1.31 Impact Factor
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