Malignant lesions of the ovary in childhood.
ABSTRACT Approximately half of all lesions of the ovary in childhood are neoplastic, yet only a small fraction of neoplastic lesions contain malignant elements. Overall, malignancies of the ovary account for 10% of all ovarian masses and 1% of childhood cancers. Primary ovarian malignancies fall into three broad categories based on the cell type of origin. Germ cell tumors predominate and may be further subdivided based on the differentiation of the malignant cells. Epithelial cell tumors, which are most common in adults, and sex-cord stromal tumors each make up 15% of the total in children. Rare malignant lesions and metastatic disease account for the small remaining group of tumors. Regardless of tumor type, the majority of patients present with localized disease, but proper surgical staging is important to determine the need for adjuvant therapy. The development of platinum-based chemotherapeutic regimens has resulted in significant improvements in long-term survival, even for children who present with advanced stage disease.
- SourceAvailable from: Robert E Bristow[Show abstract] [Hide abstract]
ABSTRACT: Adnexal masses are uncommon in the pediatric and adolescent population. The differential diagnosis includes ovarian lesions, tubal or paratubal lesions, nongynecologic lesions, and lesions related to infection or pregnancy. Presenting symptoms vary and may include acute abdominal pain, mass effect, and less commonly, precocious puberty and vaginal bleeding. Most of these lesions represent benign pathology, but malignant lesions are identified in a small subset of patients, and appropriate surgical and postoperative management is essential. It is important for clinicians caring for these patients to understand the differential diagnosis of an adnexal mass, to facilitate correct management (whether surgical or nonsurgical) and necessary referrals where appropriate. This review explores the etiologies, presenting symptoms, and appropriate management options for pediatric and adolescent patients with adnexal masses. There are few clinical trials guiding the management of these patients, and existing data comprise primarily case series and retrospective studies.03/2011; 1(1). DOI:10.1007/s13669-011-0001-4
Article: Ovarian Lesions
Conference Paper: Explosive pulsed power experiments at the Phillips Laboratory[Show abstract] [Hide abstract]
ABSTRACT: The application of pulsed power technology to advanced aerospace mission scenarios increasingly involves achieving higher peak power and energy while shrinking the deployment package. The inherent high energy density of explosives make them an obvious candidate for applications requiring extremely compact, single shot pulsed power drivers. However, explosive flux compression generators tend to be rather slow, low impedance, high current devices, while the loads of interest typically present a relatively high impedance and require short, high voltage pulses. In this paper, the results of experiments involving helical explosive generators and pulse shaping/impedance matching systems are discussedPulsed Power Conference, 1997. Digest of Technical Papers. 1997 11th IEEE International; 01/1997