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Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease

William Penn University, Filadelfia, Pennsylvania, United States
Annals of Neurology (Impact Factor: 11.91). 05/2005; 57(5):721-9. DOI: 10.1002/ana.20477
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ABSTRACT We assessed cerebrospinal fluid (CSF) levels of tau and other biomarkers of neurodegenerative disease. CSF tau levels vary widely in reports of frontotemporal dementia (FTD). CSF samples were assayed for tau, amyloid beta1-42 (A1-42), and the isoprostane 8,12-iso-iPF2a-VI (iP) prospectively in 64 patients with FTD, retrospectively in 26 autopsied cases with FTD or Alzheimer's disease (AD), and in 13 healthy seniors. To validate our observations in vivo, we correlated CSF tau levels with cortical atrophy in 17 FTD patients using voxel-based morphometry analyses of high-resolution magnetic resonance imaging. CSF levels of tau, Abeta1-42, and iP differed significantly in FTD compared with AD. Individual patient analyses showed that 34% of FD patients had significantly low levels of CSF tau, although this was never seen in AD. A discriminant analysis based on CSF levels of tau, Abeta1-42, and iP was able to classify 88.5% of these patients in a manner that corresponds to their clinical or autopsy diagnosis. Magnetic resonance imaging studies showed that CSF tau levels correlate significantly with right frontal and left temporal cortical atrophy, brain regions known to be atrophic in patients with autopsy-proved FTD. We conclude that CSF tau levels are significantly reduced in many patients with FTD.

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    • "Therefore, there is an urgent need for objective diagnostic tests of AD onset and progression. AD biomarkers based on imaging and body fluid analytes have been proposed and the combined detection of three well recognized CSF biomarkers: Aβ1-42, total tau and phosphorylated tau (p-tau) reach high sensitivity and specificity for AD prediction (Grossman et al., 2005; Jack et al., 2010; Mulder et al., 2010; Petersen et al., 2010). However, a significant limitation to these methods is represented by their costs, availability and invasiveness that impede their routine use especially for the diagnosis of asymptomatic early stages of AD. "
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    • ") CN AD < FTLD, CN CN < FTLD < AD NA No statistical analysis of FTLD diagnostic accuracy performed Grossman et al., 2005 "
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    Frontiers in Aging Neuroscience 02/2013; 5:6. DOI:10.3389/fnagi.2013.00006 · 2.84 Impact Factor
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    • "Compared with Alzheimer's disease, elevated tau or reduced amyloid-b 1–42 are usually not found in other forms of neurodegenerative dementia (e.g. tauopathies, vascular dementia, Lewy body disease) (Grossman et al., 2005; Hu et al., 2010). A recent large US cohort study analysed CSF dementia marker profiles on neurodegenerative dementia (Schoonenboom et al., 2012) and obtained similar results as the study presented here. "
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