Liquorice and hypertension

The Netherlands Journal of Medicine (Impact Factor: 2.21). 05/2005; 63(4):119-20.
Source: PubMed

ABSTRACT Glycyrrhetinic acid, the active constituent of liquorice, inhibits renal IIbeta-hydroxysteroid dehydrogenase. This allows cortisol to stimulate mineralocorticoid receptors, which can result in hypertension and hypokalaemia. Treatment options are based on pathophysiological understanding.

Download full-text


Available from: Stan van uum, Mar 01, 2015
  • [Show abstract] [Hide abstract]
    ABSTRACT: Taiwan has the greatest incidence rate of end-stage renal disease in the world. Several cases of Chinese herb nephropathy were reported in Taiwan. Therefore, we studied the association between herbal therapy and chronic kidney disease (CKD) in Taiwan. Cross-sectional survey. 1,740 adults in the Nutrition and Health Survey in Taiwan (1993 to 1996). Herbal and analgesic therapy. CKD after adjustment for potential confounding variables. Among medication users, prevalences of herbal therapy and analgesic use were 21.6% and 13.2%, respectively. The prevalence of CKD was 9.9%. Participants with CKD were older and had more analgesic use, diabetes, hypertension, and cardiovascular disease. Analgesic use was associated independently and positively with CKD (odds ratio, 2.2; 95% confidence interval, 1.4 to 3.5; P = 0.003) and CKD stage (odds ratio, 2.3; 95% confidence interval, 1.4 to 3.6; P = 0.003). Conversely, herbal therapy was associated independently and positively with CKD (odds ratio, 1.39; 95% confidence interval, 1.2 to 1.7; P = 0.002) and CKD stage (odds ratio, 1.38; 95% confidence interval, 1.1 to 1.7; P = 0.004) only in participants who did not use analgesics. Because this was a cross-sectional study, cause and effect could not be ascertained. Herbal therapy was associated with CKD in adults in Taiwan who did not use analgesics.
    American Journal of Kidney Diseases 06/2007; 49(5):626-33. DOI:10.1053/j.ajkd.2007.02.259 · 5.76 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Consumption of large quantities of liquorice can cause hypokalemia and hypertension. These effects are associated with increased cortisol-mediated activation of renal mineralocorticoid receptors and hypoaldosteronism. The authors describe a patient with long-standing hypokalemia and uncontrolled hypertension related to excessive ingestion of liquorice. The case highlights the importance of obtaining a detailed dietary history, especially considering the increasing use of liquorice-containing foods, teas, and herbal products. The authors also discuss secondary causes of hypertension, focusing on pseudohyperaldosteronism.
    Journal of Clinical Hypertension 03/2008; 10(2):153-7. DOI:10.1111/j.1751-7176.2008.07470.x · 2.96 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The roots and rhizomes of licorice (Glycyrrhiza) species have long been used worldwide as a herbal medicine and natural sweetener. Licorice root is a traditional medicine used mainly for the treatment of peptic ulcer, hepatitis C, and pulmonary and skin diseases, although clinical and experimental studies suggest that it has several other useful pharmacological properties such as antiinflammatory, antiviral, antimicrobial, antioxidative, anticancer activities, immunomodulatory, hepatoprotective and cardioprotective effects. A large number of components have been isolated from licorice, including triterpene saponins, flavonoids, isoflavonoids and chalcones, with glycyrrhizic acid normally being considered to be the main biologically active component. This review summarizes the phytochemical, pharmacological and pharmacokinetics data, together with the clinical and adverse effects of licorice and its bioactive components.
    Phytotherapy Research 06/2008; 22(6):709-24. DOI:10.1002/ptr.2362 · 2.40 Impact Factor
Show more