Article

Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data.

Department of Nutritional Toxicology, Institute for Nutritional Sciences, Friedrich-Schiller-University Jena, Germany.
British Journal Of Nutrition (Impact Factor: 3.34). 05/2005; 93 Suppl 1:S73-90. DOI: 10.1079/BJN20041349
Source: PubMed

ABSTRACT Inulin-type fructans (beta(2,1)fructans) extracted from chicory roots (Cichorium intybus) are prebiotic food ingredients, which in the gut lumen are fermented to lactic acid and SCFA. Research in experimental animal models revealed that inulin-type fructans have anticarcinogenic properties. A number of studies report the effects of inulin-type fructans on chemically induced pre-neoplastic lesions (ACF) or tumours in the colon of rats and mice. In twelve studies, there were twenty-nine individual treatment groups of which twenty-four measured aberrant crypt foci (ACF) and five measured tumours. There was a significant reduction of ACF in twenty-one of the twenty-four treatment groups and of tumour incidence in five of the five treatment groups. Higher beneficial effects were achieved by synbiotics (mixtures of probiotics and prebiotics), long-chain inulin-type fructans compared to short-chain derivatives, and feeding high-fat Western style diets. Inulin-type fructans reduced tumour incidence in APC(Min) mice in two of four studies and reduced growth and metastasising properties of implanted tumour cells in mice (four studies). The effects have been reported to be associated with gut flora-mediated fermentation and production of butyrate. In human cells, inulin-derived fermentation products inhibited cell growth, modulated differentiation and reduced metastasis activities. In conclusion, evidence has been accumulated that shows that inulin-type fructans and corresponding fermentation products reduced the risks for colon cancer. The involved mechanisms included the reduction of exposure to risk factors and suppression of tumour cell survival. Thus, this specific type of dietary fibre exerted both blocking agent and suppressing agent types of chemopreventive activities.

0 Followers
 · 
190 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: The modifying effects of aqueous yacon extract (AYE) and L. acidophilus CRL 1014 against colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats were investigated. Animals were allocated into five groups: G1: untreated group; G2: DMH-treated group; G3: DMH + L. acidophilus- treated group; G4: DMH + AYE-treated group; G5: DMH + L. acidophilus and AYE-treated group. A significant reduction (p<0.05) in leukocyte DNA damage and in colonic cell proliferation were observed after the first DMH administration in G3 (probiotic), G4 (prebiotic) and G5 (synbiotic) groups. In this moment, a significant increase (p<0.05) in colonic apoptosis was also observed in G3 (probiotic) and G5 (synbiotic) groups. In special, at five months after DMH administrations, a significant reduction (p < 0.05) in ACF development was observed in G3 (probiotic), G4 (prebiotic) and G5 (synbiotic) groups. Incidence of colon tumors was lower at five months in G4 (prebiotic) and G5 (synbiotic) groups but not in eight months after DMH administrations. In conclusion, the findings suggest that the oral treatments have potential effects as a chemopreventive agent against colon carcinogenesis on early stage of tumor development.
    Food Research International 04/2015; 74. DOI:10.1016/j.foodres.2015.04.034 · 3.05 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Natural polysaccharides from different sources have long been studied and widely used in different areas, such as food and feed, medicine and pharmaceutics, and in papermaking. In recent decades, there has been an increased interest in the utilization of polysaccharides, particularly bioactive ones, for various novel applications owing to their biocompatibility, biodegradability, non-toxicity, and some specific therapeutic activities. The main goal of this paper was to review the sources, natively biological activities, isolation, characterization, and the structural features of natively bioactive polysaccharides. Moreover, the article has also been forcused on the chemical/chemo-enzymatic functionalizations that may create novel opportunities to maximally exploit the various valuable properties of polysaccharides, particularly from wood species, in previously unperceived applications especially for biomedical applications, such as tissue engineering, wound healing, and drug delivery. This article was to review novel strategies to tailor functional materials with above mentioned application potentials for the polysaccharides from wood species.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Natural polysaccharides from different sources have long been studied and widely used in different areas, such as food and feed, medicine and pharmaceutics, and in papermaking. In recent decades, there has been an increased interest in the utilization of polysaccharides, particularly bioactive ones, for various novel applications owing to their biocompatibility, biodegradability, non-toxicity, and some specific therapeutic activities. The main goal of this paper was to review the sources, natively biological activities, isolation, characterization, and the structural features of natively bioactive polysaccharides. Moreover, the article has also been forcused on the chemical/chemo-enzymatic functionalizations that may create novel opportunities to maximally exploit the various valuable properties of polysaccharides, particularly from wood species, in previously unperceived applications especially for biomedical applications, such as tissue engineering, wound healing, and drug delivery. This article was to review novel strategies to tailor functional materials with above mentioned application potentials for the polysaccharides from wood species.
    01/2015; 5(1):31-61. DOI:10.1016/j.bcdf.2014.12.001

Preview

Download
5 Downloads
Available from