Number of Lymph Node Metastases Is a Significant Prognostic Factor in Intrahepatic Cholangiocarcinoma

Department of General Surgery, Hokkaido University, Graduate School of Medicine, N15W7, Kita-ku, Sapporo, Japan.
World Journal of Surgery (Impact Factor: 2.64). 07/2005; 29(6):728-33. DOI: 10.1007/s00268-005-7761-9
Source: PubMed


Intrahepatic cholangiocarcinoma (IHCC) is a rare primary hepatic tumor. Outcomes after resection and the use of lymph node dissection have not been well described. From a prospective database, we identified 53 patients with IHCC who underwent exploration between April 1983 and March 2004. Hepatic resection was performed in 44 patients, 30 of whom underwent lymph node dissection. Clinicopathological features and outcomes were analyzed. The actuarial 1-year survival was 66.2% in resected patients, compared to 0% in unresectable patients (p < 0.0001), with a 50% overall survival of 21.5 months and 3.1 months, respectively. The actuarial 3-year and 5-year overall survival rates in resected patients were 38.3% and 26.3%, respectively. Univariate analysis revealed that factors associated with poor overall survival included multiple tumors, extrahepatic bile duct involvement, noncurative resection, and involvement of lymph nodes. Multivariate analysis in resected patients revealed that multiple tumors (p < 0.0074) and non-curative resection (p = 0.0068) were significant risk factors for poor overall survival. The survival rate in patients with three or more positive nodes was significantly lower than in those with fewer than three (p < 0.0001). Three patients with solitary tumors and one or two involved lymph nodes have survived beyond 4 years after extended lobectomy with systemic lymphadenectomy. Curative resection, single tumor, and fewer than two lymph node metastases were prognostic factors for good outcome. Curative resection with lymph node dissection improved survival in patients with no more than two positive lymph nodes.

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    • "While removal of clinically suspicious nodal disease is mandatory , the role of routine lymphadenectomy is less defined. In contrast to the practice of many Japanese centers, lymph node dissection is not routinely performed at the time of iCCA resection in most Western countries [156]. In fact, in a large population-based "
    Journal of Hepatology 06/2014; 60(6). DOI:10.1016/j.jhep.2014.01.021 · 11.34 Impact Factor
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    • "The prognosis of CCA is poor with an overall median reported survival of less than 1 year after diagnosis [4]. Surgery is the only curative treatment option at this time, with resectability rates ranging from 36% to 77% [5,6]. Serum carbohydrate antigen (CA19-9) has been extensively studied and is the most common tumour marker used in assisting in the diagnosis and monitoring of CCA [7]. "
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    ABSTRACT: The aim of this discovery study was the identification of peptide serum biomarkers for detecting biliary tract cancer (BTC) using samples from healthy volunteers and benign cases of biliary disease as control groups. This work was based on the hypothesis that cancer-specific exopeptidase activities in serum can generate cancer-predictive peptide fragments from circulating proteins during coagulation. This case control study used a semi-automated platform incorporating polypeptide extraction linked to matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS) to profile 92 patient serum samples. Predictive models were generated to test a validation serum set from BTC cases and healthy volunteers. Several peptide peaks were found that could significantly differentiate BTC patients from healthy controls and benign biliary disease. A predictive model resulted in a sensitivity of 100% and a specificity of 93.8% in detecting BTC in the validation set, whilst another model gave a sensitivity of 79.5% and a specificity of 83.9% in discriminating BTC from benign biliary disease samples in the training set. Discriminatory peaks were identified by tandem MS as fragments of abundant clotting proteins. Serum MALDI MS peptide signatures can accurately discriminate patients with BTC from healthy volunteers.
    BMC Clinical Pathology 02/2014; 14(1):7. DOI:10.1186/1472-6890-14-7
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    • "Lymph node metastasis (LNM) has been reported to be a significant prognostic factor in ICC (Hanazaki et al., 2002; Fu et al., 2004; Nakagawa et al., 2005; Choi et al., 2009; Guglielmi et al., 2009; Saxena et al., 2010b). It is also important to decide whether a patient with ICC should be considered for irradiation of the regional lymph nodes. "
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    ABSTRACT: Purpose: This study was conducted to identify factors involved in lymph node metastasis (LNM) and evaluate their role in predicting LNM in clinically lymph node negative (clinical stage I-III) intrahepatic cholangiocarcinoma (ICC). Materials and Methods: We selected 320 patients who were diagnosed with ICC with no apparent clinical LNM (T(1-3)N(0)M(0)). Age, gender, tumor boundary, histological differentiation, tumor size, and carbohydrate antigen 19-9 value were the studied factors. Univariate and multivariate logistic analysis were conducted. Receiver operating characteristics curve analysis was used to test the predicting value of each factor and a test which combined the associated factors was used to predict LNM. Results: LNM was observed in 76 cases (76/320, 23.8%). Univariate and multivariate analysis showed that histological differentiation as well as tumor boundary and tumor size significantly correlated with LNM. The sensitivity and negative predictive value for LNM for the three factors when combined was 96.1 and 95% respectively. This means that 5% of the patients who did not have the risk factors mentioned above developed LNM. Conclusion: This model used the combination of three factors (low-graded histological differentiation, distinct tumor boundary, small tumor size) and they proved to be useful in predicting LNM in ICC with clinically lymph node negative cases. In patients with these criteria, lymph node dissection or lymph node irradiation may be omitted and such cases may also be good candidates for stereotactic body radiotherapy (SBRT).
    Frontiers in Oncology 11/2011; 1:42. DOI:10.3389/fonc.2011.00042
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