Physical activity and sexual functioning after radiotherapy for prostate cancer: Beneficial effects for patients undergoing external beam radiotherapy
ABSTRACT To evaluate, in a cross-sectional study, the relationships among physical activity, sexual functioning, and treatment type for 111 men who had undergone radiotherapy for localized prostate cancer within the past 18 months. Physical activity preserves the sexual functioning capacity of older men. However, little information exists regarding the association of physical activity with sexual functioning after treatment for localized prostate cancer.
We tested the main effects of physical activity and treatment procedure, as well as their interaction, using hierarchical regression analysis. We hypothesized that greater physical activity would relate to better reported sexual functioning and that this relationship would be moderated by the type of medical treatment.
After controlling for age, medical comorbidity, fatigue, and urinary and bowel functioning, more physical activity was significantly associated with better sexual functioning, and the interaction of physical activity and treatment procedure added a significant amount of explained variance. Overall, 35% of the variance in sexual functioning was accounted for by the model. Post hoc tests of moderation revealed that men who underwent external beam radiotherapy had significantly greater sexual functioning scores as physical activity increased but the effect of physical activity on sexual function after brachytherapy and combination therapy was nonsignificant.
Physical activity was positively correlated with sexual functioning for those who underwent external beam radiotherapy. These relationships should be replicated and explored in a larger, longitudinal sample to ascertain whether the effects of physical activity in this at-risk population extend over time and protect men from treatment-related decrements in sexual functioning.
SourceAvailable from: Aude-Marie Foucaut[Show abstract] [Hide abstract]
ABSTRACT: La survie après le diagnostic d’un cancer dépend de la possibilité de réaliser les traitements les plus efficaces et de la qualité de la réhabilitation après le traitement. La prise en charge nutritionnelle, qui intègre la diététique et l’activité physique, est nécessaire au maintien et à l’amélioration de la composition corporelle afin d’optimiser la réalisation de ces traitements et de la réhabilitation et doit être intégrée précocement dans le programme personnalisé de soins. La prise en charge diététique vise à éviter une dénutrition. L’activité physique a pour objet de maintenir la masse et la fonction musculaires et, après la rémission du cancer, de réduire une surcharge adipeuse ; elle améliore incontestablement la fatigue liée au cancer et à ses traitements ainsi que la qualité de vie et peut avoir un effet sur la survie spécifique ou globale.Nutrition Clinique et Métabolisme 11/2014; DOI:10.1016/j.nupar.2014.10.007 · 0.62 Impact Factor
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ABSTRACT: Background:Previous research has shown exercise to be an effective method to mitigate many adverse treatment-related effects of androgen suppression therapy (AST) but the potential impact of exercise on sexual activity remains unknown. The purpose of this investigation was to report the effect of a 12-week exercise program on sexual activity in prostate cancer patients undergoing AST.Methods:Fifty-seven prostate cancer patients undergoing AST were randomly assigned to an exercise program (resistance and aerobic modes; n=29) or usual care control (n=28). Sexual activity was assessed by the European Organization for Research and Treatment of Cancer prostate cancer-specific quality of life questionnaire (QLQ-PR25).Results:QLQ-PR25 data were log transformed and analysis of covariance was used to compare sexual activity between groups following the intervention adjusted for baseline activity. No differences in sexual activity were observed between the exercise and control groups before the intervention. There was a significant (P=0.045) adjusted group difference in sexual activity following the 12-week intervention. Patients undergoing usual care decreased sexual activity while patients in the exercise program maintained their level of sexual activity. At baseline, 20.6 and 22.2% of participants in the exercise and control groups reported a major interest in sex (that is, high libido). Following the intervention, the exercise group had a significantly higher percentage of participants reporting a major interest in sex (exercise=17.2% vs control=0%; P=0.024).Conclusions:Participation in a short-term exercise program resulted in the maintenance of sexual activity in prostate cancer patients undergoing AST.Prostate Cancer and Prostatic Disease advance online publication, 15 January 2013; doi:10.1038/pcan.2012.52.Prostate cancer and prostatic diseases 01/2013; DOI:10.1038/pcan.2012.52 · 2.83 Impact Factor
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ABSTRACT: Sexual dysfunction is one of the most common, distressing and persistent adverse effects of prostate cancer treatment, and has a profound effect on quality of life for the patient and his partner. Current health-care provisions are inadequate to address the demand for the management of sexual dysfunction, with approximately half of prostate cancer survivors reporting unmet sexual health-care needs. Management strategies predominately involve pharmacological interventions to address the direct physiological effects of prostate cancer treatment on erectile function. However, the aetiology of sexual dysfunction is multifaceted and considerable physiological and psychological adverse effects of prostate cancer treatments, which are not addressed by pharmacological intervention, contribute to sexual dysfunction. Exercise has established efficacy for improving many of these factors in men with prostate cancer, including changes in body composition (especially to counteract body feminization), fatigue, physical function, risk of comorbid conditions, depression, anxiety and quality of life. Emerging evidence indicates that exercise also has a positive effect on sexual desire and sexual activity in men with prostate cancer.Nature Reviews Urology 10/2013; 10(12). DOI:10.1038/nrurol.2013.206 · 4.52 Impact Factor