Differential expression of cytokines in the brain and serum during endotoxin tolerance.

Department of Biology, Seton Hall University, 400 South Orange Avenue, South Orange, NJ 07079, USA.
Journal of Neuroimmunology (Impact Factor: 2.79). 07/2005; 163(1-2):53-72. DOI: 10.1016/j.jneuroim.2005.02.012
Source: PubMed

ABSTRACT Using short- and long-course lipopolysaccharide (LPS) treatment regimens to induce endotoxin tolerance in rats, we compared TNF-alpha, IL-1beta, and IL-6 expression in the brain and serum following a LPS challenge. Serum corticosterone was also examined to evaluate the function of the hypothalamic-pituitary-adrenal (HPA) axis. We found that, during endotoxin tolerance, LPS-induced cytokine expression still occurred in the brain even when cytokines in the periphery were no longer induced, and that this differential cytokine expression may be mediated by corticosterone, a stress hormone and an anti-inflammatory agent.

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