Article

FcgammaRIIIb and complement component C7 codeficiency in a patient with recurrence of fulminant meningococcal septic shock.

Immunology Laboratory, Lyon-Sud University Hospital, Pierre-Benite, France.
Clinical Infectious Diseases (Impact Factor: 9.37). 07/2005; 40(11):1679-83. DOI: 10.1086/430065
Source: PubMed

ABSTRACT Individuals with deficiencies of the late components of complement exhibit a susceptibility to the recurrence of meningococcal disease with a usually mild clinical presentation. We report the recurrence of fulminant meningococcal disease in a complement component C7-deficient patient. We found a total deficiency of FcgammaRIIIb on neutrophils, which could partially explain the unusually severe clinical presentation.

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