Histamine at high dilution reduces spectral density in delta band in sleeping rats.
ABSTRACT Histamine is a central neurotransmitter, it increases arousal via H1 receptors. This study examines the effect of ultra-diluted histamine on arousal through changes in the sleep pattern of Wistar rats. The spectral density in delta (0.5-2.5 Hz) band, one of the three major spectral components of the sleep-electroencephalogram, was analyzed against time. Rats were randomized to receive histamine 30c (histamine 30c, 0.05 ml every 20 min during the first 2 h orally), histamine intraperitoneal pre-treatment/histamine 30c (histamine 6mg/kg i.p., followed by histamine 30c) or solvent control. The mean delta band spectral density was lower in the histamine 30c and histamine pretreatment/histamine 30c groups than the control group. Significant differences between histamine 30c and baseline during the first 2 h imply an immediate effect. These results also suggest a dynamic process in which the system spontaneously evolves between two locally stationary states according to a power law. From the time perspective, the system approaches, asymptotically, an equifinal state.
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ABSTRACT: L’opera ‘Farmacologia delle alte diluizioni’ rappresenta un originale contributo alla letteratura sulla questione omeopatica, di notevole interesse anche alla luce della crescente diffusione di questa disciplina nel mondo medico e del favore che riscontra presso il pubblico. Questa è l'edizione italiana del libro dei Sukul, tradotta e commentata da Paolo Bellavite, che ha scritto anche un ampio capitolo introduttivo di rassegna sullo stato delle conoscenze al tempo.Edited by Paolo Bellavite, 01/2005; Salus Infirmorum, Padova, 2005.
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ABSTRACT: Riassunto Sono riportati i principali esperimenti svolti nel nostro laboratorio, mediante metodi rigorosi, attendibili e riproducibili, i cui risultati dimostrano che Istamina inibisce l'attivazione dei basofili umani e Gelsemium e Ignatia hanno effetti ansiolitici su modelli murini di comportamento. Tali sostanze agiscono in diluizioni/dinamizzazioni di tipo omeopatico, anche superiori alla costante di Avogadro-Loschmidt. Si presenta infine una ipotesi sintetica e generale dell'effetto omeopatico. Summary We report (Italian) the main experimental lines of our laboratory, where through rigorous and reliable methods we have shown that histamine inhibits the human basophil activation and Gelsemium and Ignatia regulate anxiety-like behaviours in laboratory mouse. These agents work also in dilutions/dynamizations which are beyond the Avogadro-Loschmidt constant. At the end we suggest a general hypothesis regarding the homeopathic effects.1° congresso Internazionale di Medicina Integrata, Roma, Pontificia Università Lateranense; 02/2012
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ABSTRACT: The pharmacodynamics aspects of homeopathic remedies are appraised by laboratory studies on the biological effects at various levels (cellular, molecular and systemic). The major question is how these medicines may work in the body. The possible answers concern the identification of biological targets, the means of drug-receptor interactions, the mechanisms of signal transmission and amplification, and the models of inversion of effects according to the traditional 'simile' rule. These problems are handled by two experimental and theoretical lines, according to the doses or dilutions considered (low-medium versus high dilutions). Homeopathic formulations in low-medium dilutions, containing molecules in the range of ultra-low doses, exploit the extreme sensitivity of biological systems to exogenous and endogenous signals. Their effects are interpreted in the framework of hormesis theories and paradoxical pharmacology. The hypotheses regarding the action mechanisms of highly diluted/dynamized solutions (beyond Avogadro-Loschmidt limit) variously invoke sensitivity to bioelectromagnetic information, participation of water chains in signalling, and regulation of bifurcation points of systemic networks. High-dilution pharmacology is emerging as a pioneering subject in the domain of nanomedicine and is providing greater plausibility to the puzzling claims of homeopathy.Homeopathy: the journal of the Faculty of Homeopathy 01/2014; 103(1):22-43. DOI:10.1016/j.homp.2013.08.002 · 1.13 Impact Factor