Histamine is a central neurotransmitter, it increases arousal via H1 receptors. This study examines the effect of ultra-diluted histamine on arousal through changes in the sleep pattern of Wistar rats. The spectral density in delta (0.5-2.5 Hz) band, one of the three major spectral components of the sleep-electroencephalogram, was analyzed against time. Rats were randomized to receive histamine 30c (histamine 30c, 0.05 ml every 20 min during the first 2 h orally), histamine intraperitoneal pre-treatment/histamine 30c (histamine 6mg/kg i.p., followed by histamine 30c) or solvent control. The mean delta band spectral density was lower in the histamine 30c and histamine pretreatment/histamine 30c groups than the control group. Significant differences between histamine 30c and baseline during the first 2 h imply an immediate effect. These results also suggest a dynamic process in which the system spontaneously evolves between two locally stationary states according to a power law. From the time perspective, the system approaches, asymptotically, an equifinal state.
[Show abstract][Hide abstract] ABSTRACT: L’opera ‘Farmacologia delle alte diluizioni’ rappresenta un originale contributo alla letteratura sulla questione omeopatica, di notevole interesse anche alla luce della crescente diffusione di questa disciplina nel mondo medico e del favore che riscontra presso il pubblico. Questa è l'edizione italiana del libro dei Sukul, tradotta e commentata da Paolo Bellavite, che ha scritto anche un ampio capitolo introduttivo di rassegna sullo stato delle conoscenze al tempo.
Edited by Paolo Bellavite, 01/2005; Salus Infirmorum, Padova, 2005.
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