Retinoic acid isomers protect hippocampal neurons from amyloid-beta induced neurodegeneration.
ABSTRACT Attenuating amyloid-beta mediated neurodegeneration is of major therapeutic consideration in the potential treatment of Alzheimer disease. Previously, we found that a high dietary consumption of retinoic acid was associated with a reduced incidence of Alzheimer disease. Therefore, in this study, we investigated whether amyloid-beta mediated cell death in primary hippocampal neurons could be prevented by retinoic acid isomers. Our results suggest that retinoic acid isomers, including all-trans retinoic acid, 9-cis retinoic acid, and 13-cis retinoic acid, may play an important role in protecting neurons from amyloid-beta -induced cell death. Retinoic acid may therefore afford a novel therapeutic mechanism for the treatment and prevention of Alzheimer disease.
- SourceAvailable from: Alejandro GellaAlzheimer's Disease Pathogenesis-Core Concepts, Shifting Paradigms and Therapeutic Targets, 09/2011; , ISBN: 978-953-307-690-4
- Neurochemistry International 06/2011; 59(5):535-41. · 2.66 Impact Factor
- Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 07/2011; 159(3):171-82. · 1.61 Impact Factor