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Gervasoni N, Aubry JM, Bondolfi G, Osiek C, Schwald M, Bertschy G, Karege F 2005. Partial normalization of serum brain-derived neurotrophic factor in remitted patients after a major depressive episode

Department of Psychiatry, University of Geneva, Genève, Geneva, Switzerland
Neuropsychobiology (Impact Factor: 2.3). 02/2005; 51(4):234-8. DOI: 10.1159/000085725
Source: PubMed

ABSTRACT We had previously reported decreased serum brain-derived neurotrophic factor (BDNF) levels in depressed patients. In the present study, we tested the hypothesis that antidepressant treatment would normalize serum BDNF levels, at least in a subgroup of patients. Major depressed patients (15 females and 11 males) diagnosed according to DSM-IV criteria and healthy controls (13 females and 13 males) participated in this study. Serum BDNF was assayed with the ELISA method for depressed and remitted patients and the severity of depression was evaluated with the Montgomery-Asberg Depression Rating Scale. An analysis of variance showed that treatment had an effect [F(1, 24) = 4.46, p = 0.045] on the normalization of serum BDNF levels. We also found a correlation between the severity of depression (r = 0.51, p = 0.008), the pretreatment BDNF levels (r = 0.62, p = 0.001) and the difference in serum BDNF levels after antidepressant treatment. These results suggest that antidepressant treatment has a positive effect on serum BDNF levels and support the hypothesis of neurotrophic factor involvement in affective disorders.

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    • "Upregulation of BDNF may reverse stress-induced deficits in structural and synaptic plasticity in the adult brain, resulting in cognitive flexibility and an increased ability to adapt with environmental challenges that may precipitate or exacerbate depressive episodes. Recent studies demonstrate that BDNF levels are decreased in the blood of depressed patients and its levels are increased with antidepressant treatment (Aydemir et al., 2005; Brunoni et al., 2008; Deuschle et al., 2013; Gervasoni et al., 2005; Karege et al., 2002; Kim et al., 2007; Lee et al., 2006, 2011; Ricken et al., 2013; Sen et al., 2008; Shimizu et al., 2003). Moreover, human BDNF polymorphism and serum levels have been connected with anxiety, risk of depression, neuroticism and serotonergic neurotransmission (Lang et al., 2002; 2004, 2005a, 2005b, 2007, 2009a, 2009b). "
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    • "Logistic regressions were run to examine the relationship between BDNF and remissions status. The model was adjusted for variables (age, gender, smoking, illness duration, antidepressant use, antipsychotic type and dosage) which were previously found to influence serum BDNF levels in an effort to minimise potentially confounding influence (Chen and Huang, 2011; Gervasoni et al., 2005; Green et al., 2011; Nurjono et al., 2012; Trajkovska et al., 2007; Wang et al., 2007; Xiu et al., 2009 "
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    • "This suggests that rTMS effects on peripheral BDNF levels depend on whether study participants are depressed or not. rTMS may entail both, a decrease of peripheral BDNF in healthy participants with physiological BDNF serum levels and an increase in depressed patients who show a ` priori-reduced BDNF levels (Duman and Monteggia 2006; Gervasoni et al. 2005; Lee et al. 2007). This might indicate a role of BDNF in a negative feedback loop. "
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