Article

The role of natural antibodies in atherogenesis.

Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
The Journal of Lipid Research (impact factor: 5.56). 08/2005; 46(7):1353-63. DOI:10.1194/jlr.R500005-JLR200 pp.1353-63
Source: PubMed

ABSTRACT Atherosclerosis is now widely recognized as a chronic inflammatory disease that involves innate and adaptive immune responses. Both cellular and humoral components of the immune system have been implicated in atherogenesis. Natural antibodies can be considered humoral factors of innate immunity, and their functional role in health and disease has been reexamined in recent years. Natural antibodies exhibit a remarkably conserved repertoire that includes a broad specificity for self-antigens. For this reason, they are believed to be a product of natural selection and have been suggested to play an important role in "housekeeping" functions. Recent evidence has revealed that oxidation-specific epitopes are important and maybe immunodominant targets of natural antibodies, suggesting an important function for these antibodies in the host response to consequences of oxidative stress, for example, to the oxidative events that occur when cells undergo apoptosis. This review will focus on these recent findings and discuss the emerging evidence for an important role of natural antibodies in atherogenesis.

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Keywords

atherogenesis
 
Atherosclerosis
 
chronic inflammatory disease
 
consequences
 
conserved repertoire
 
emerging evidence
 
functional role
 
functions
 
host response
 
humoral components
 
humoral factors
 
immunodominant targets
 
innate immunity
 
involves innate
 
natural selection
 
oxidation-specific epitopes
 
oxidative events
 
oxidative stress
 
Recent evidence