Protein microarray for profiling antibody responses to Yersinia pestis live vaccine.

Laboratory of Analytical Microbiology, National Center for Biomedical Analysis, Army Center for Microbial Detection and Research, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.
Infection and Immunity (Impact Factor: 4.07). 07/2005; 73(6):3734-9. DOI: 10.1128/IAI.73.6.3734-3739.2005
Source: PubMed

ABSTRACT A protein microarray representing 149 Yersinia pestis proteins was developed to profile antibody responses in EV76-immunized rabbits. Antibodies to 50 proteins were detected. There are 11 proteins besides F1 and V antigens to which the predominant antibody response occurred, and these proteins show promise for further evaluation as candidates for subunit vaccines and/or diagnostic antigens.

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