[Functional-morphologic aspects of changes of mucosal gingiva microcirculatory bed vessels in experimental gingivitis against the background of hypercholesterolemia].

Natishvili A.N. Research Institute of Experimental Morphology, Tbilisi, Georgia.
Georgian medical news 05/2005;
Source: PubMed

ABSTRACT The study of mucosal gingiva microcirculatory bed in conditions modeling the change of vascular wall permeability that promotes cell migration and plasmorrhagia. The experiments were made on 3 groups of chinchilla rabbits--body weight 1,7-2,5 kg: I-experimental gingivitis (10 animals); II-experimental hypercholesterolemia--the rabbits received aterogenic diet (0,3 g/kg of cholesterol) (10 animals). Two month after the aterogenic diet, gingivitis was modelled against the background of hypercholesterolemia (control for group II). IV-series--conditionally "normal"--5 rabbits. The light-optic and electron microscopic studies have revealed significant changes in extracellular matrix and gingiva mucous cells as well as in microcirculatory bed components in hypercholesterolemia. Hypercholesterolemia damages endotheliocytes, subendothelial zone, basal membrane abd changes permeability. The contact of lymphocytes and plasmocytes with the vascular wall confirms the trigger role of the vascular factor in damaging of periodontal complex.

  • [Show abstract] [Hide abstract]
    ABSTRACT: There is increasing evidence of a relationship between periodontitis and several nutrition-linked chronic conditions, such as obesity, dyslipidaemia and metabolic syndrome, with a putative bidirectional influence between periodontal disease and each condition. An association between several dietary factors and the progression of periodontitis is relevant to this relationship. Thus, omega-3 fatty acids, vitamin C, lactic acid foods, soy products and a diet rich in vegetables and fresh food appear to be favourable for better periodontal health, whereas a lipid-rich diet may be detrimental to periodontal tissues.
    Mediterranean Journal of Nutrition and Metabolism 09/2009; 2(2):103-109. DOI:10.1007/s12349-009-0055-2
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: It has been proposed for several decades that infections may be responsible for the accelerated development of atherosclerosis. The initiation of the atherosclerotic plaque is ascribed to focal accumulation of lipids. This explains the importance of plasma lipids in the development of atherosclerosis. Recent reports point towards a possible association between periodontal disease and increased risk for cardiovascular disease. Thus, periodontitis and cardiovascular disease may share common risk factors, and association between periodontitis and coronary heart disease may be due to the elevated levels of plasma lipids. Epidemiological and clinical studies have also suggested that there is a relationship between periodontal disease and impaired lipid metabolism. In this review, we summarized the potential link mechanisms in the association between periodontal infection and serum lipids.
    European journal of dentistry 05/2008; 2(2):142-6.
  • [Show abstract] [Hide abstract]
    ABSTRACT: Hyperlipidemia is a major risk factor for cardiovascular disease. Recent reports showed a possible association between periodontal disease and an increased risk for cardiovascular disease. The aim of this study was to evaluate whether hyperlipidemia has any influence on periodontal status. Fifty-one subjects with hyperlipidemia and 47 normolipidemic subjects participated in this study. Biochemical parameters, including plasma triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels, and periodontal parameters, including plaque index (PI), probing depth (PD), clinical attachment level (CAL), and percentage of sites with bleeding on probing (BOP [%]), were evaluated. The mean values of PI, PD, CAL, and BOP (%) for the hyperlipidemic group were significantly higher than those for the control group. Plasma triglyceride, total cholesterol, and LDL-C levels were significantly and positively associated with PI, PD, BOP (%), and CAL. HDL-C was significantly, but negatively, associated with CAL. Plasma triglyceride level was significantly associated with PD and BOP (%) after further analyses. The results of our study showed that patients with mild or moderate hyperlipidemia manifested higher values of periodontal parameters compared to normolipidemic individuals. Further studies are needed to determine the effect of hyperlipidemia on periodontal disease.
    Journal of Periodontology 03/2009; 80(2):267-73. DOI:10.1902/jop.2009.080104 · 2.57 Impact Factor
Show more