[Functional-morphologic aspects of changes of mucosal gingiva microcirculatory bed vessels in experimental gingivitis against the background of hypercholesterolemia].

Natishvili A.N. Research Institute of Experimental Morphology, Tbilisi, Georgia.
Georgian medical news 05/2005;
Source: PubMed

ABSTRACT The study of mucosal gingiva microcirculatory bed in conditions modeling the change of vascular wall permeability that promotes cell migration and plasmorrhagia. The experiments were made on 3 groups of chinchilla rabbits--body weight 1,7-2,5 kg: I-experimental gingivitis (10 animals); II-experimental hypercholesterolemia--the rabbits received aterogenic diet (0,3 g/kg of cholesterol) (10 animals). Two month after the aterogenic diet, gingivitis was modelled against the background of hypercholesterolemia (control for group II). IV-series--conditionally "normal"--5 rabbits. The light-optic and electron microscopic studies have revealed significant changes in extracellular matrix and gingiva mucous cells as well as in microcirculatory bed components in hypercholesterolemia. Hypercholesterolemia damages endotheliocytes, subendothelial zone, basal membrane abd changes permeability. The contact of lymphocytes and plasmocytes with the vascular wall confirms the trigger role of the vascular factor in damaging of periodontal complex.

  • [Show abstract] [Hide abstract]
    ABSTRACT: There is increasing evidence of a relationship between periodontitis and several nutrition-linked chronic conditions, such as obesity, dyslipidaemia and metabolic syndrome, with a putative bidirectional influence between periodontal disease and each condition. An association between several dietary factors and the progression of periodontitis is relevant to this relationship. Thus, omega-3 fatty acids, vitamin C, lactic acid foods, soy products and a diet rich in vegetables and fresh food appear to be favourable for better periodontal health, whereas a lipid-rich diet may be detrimental to periodontal tissues.
    Mediterranean Journal of Nutrition and Metabolism 09/2009; 2(2):103-109. DOI:10.1007/s12349-009-0055-2
  • [Show abstract] [Hide abstract]
    ABSTRACT: It has been proposed for several decades that infections may be responsible for the accelerated development of atherosclerosis. The initiation of the atherosclerotic plaque is ascribed to focal accumulation of lipids. This explains the importance of plasma lipids in the development of atherosclerosis. Recent reports point towards a possible association between periodontal disease and increased risk for cardiovascular disease. Thus, periodontitis and cardiovascular disease may share common risk factors, and association between periodontitis and coronary heart disease may be due to the elevated levels of plasma lipids. Epidemiological and clinical studies have also suggested that there is a relationship between periodontal disease and impaired lipid metabolism. In this review, we summarized the potential link mechanisms in the association between periodontal infection and serum lipids.
    European journal of dentistry 05/2008; 2(2):142-6.
    This article is viewable in ResearchGate's enriched format
  • [Show abstract] [Hide abstract]
    ABSTRACT: This study was conducted to assess the effect of improved periodontal health following periodontal treatment on metabolic lipid control of patients on anti-lipemic treatment. The study population consisted of 20 patients aged 34-62 years with diagnoses of hyperlipidemia and chronic periodontitis. All patients used statin to treat their elevated levels of low-density lipoprotein cholesterol. Blood samples were obtained for measurement of serum lipids, fasting plasma glucose, and high sensitive C-reactive protein. Periodontal parameters, including plaque index, gingival index, probing pocket depth, clinical attachment level, and percentage of bleeding on probing, were evaluated. All parameters were assessed in each subject at baseline, after 3 months as a control (at the time of periodontal treatment), and 3 months after the non-surgical periodontal treatment that included scaling and root planning. All lipid parameters decreased after the periodontal treatment, but only the decreases in total cholesterol and low-density lipoprotein cholesterol levels reached statistical significance compared to baseline (P = 0.002 and P = 0.003, respectively). Improved periodontal health may influence metabolic control of hyperlipidemia and could be considered as an adjunct to the standard measures of hyperlipidemic patient care.
    Oral Diseases 10/2010; 16(7):648-54. DOI:10.1111/j.1601-0825.2010.01668.x · 2.40 Impact Factor