The study of mucosal gingiva microcirculatory bed in conditions modeling the change of vascular wall permeability that promotes cell migration and plasmorrhagia. The experiments were made on 3 groups of chinchilla rabbits--body weight 1,7-2,5 kg: I-experimental gingivitis (10 animals); II-experimental hypercholesterolemia--the rabbits received aterogenic diet (0,3 g/kg of cholesterol) (10 animals). Two month after the aterogenic diet, gingivitis was modelled against the background of hypercholesterolemia (control for group II). IV-series--conditionally "normal"--5 rabbits. The light-optic and electron microscopic studies have revealed significant changes in extracellular matrix and gingiva mucous cells as well as in microcirculatory bed components in hypercholesterolemia. Hypercholesterolemia damages endotheliocytes, subendothelial zone, basal membrane abd changes permeability. The contact of lymphocytes and plasmocytes with the vascular wall confirms the trigger role of the vascular factor in damaging of periodontal complex.
"In an animal model, Maglakelidze et al60 have reported significant changes in extracellular matrix and gingival mucous cells as well as in microcirculatory bed components in hypercholesterolemia. Hypercholesterolemia damages endotheliocytes, subendothelial zone and basal membrane permeability. The contact of lymphocytes and plasmocytes with the vascular wall confirms the trigger role of the vascular factor in damaging of periodontal complex. "
[Show abstract][Hide abstract] ABSTRACT: It has been proposed for several decades that infections may be responsible for the accelerated development of atherosclerosis. The initiation of the atherosclerotic plaque is ascribed to focal accumulation of lipids. This explains the importance of plasma lipids in the development of atherosclerosis. Recent reports point towards a possible association between periodontal disease and increased risk for cardiovascular disease. Thus, periodontitis and cardiovascular disease may share common risk factors, and association between periodontitis and coronary heart disease may be due to the elevated levels of plasma lipids. Epidemiological and clinical studies have also suggested that there is a relationship between periodontal disease and impaired lipid metabolism. In this review, we summarized the potential link mechanisms in the association between periodontal infection and serum lipids.
European journal of dentistry 05/2008; 2(2):142-6.
[Show abstract][Hide abstract] ABSTRACT: There is increasing evidence of a relationship between periodontitis and several nutrition-linked chronic conditions, such
as obesity, dyslipidaemia and metabolic syndrome, with a putative bidirectional influence between periodontal disease and
each condition. An association between several dietary factors and the progression of periodontitis is relevant to this relationship.
Thus, omega-3 fatty acids, vitamin C, lactic acid foods, soy products and a diet rich in vegetables and fresh food appear
to be favourable for better periodontal health, whereas a lipid-rich diet may be detrimental to periodontal tissues.
Mediterranean Journal of Nutrition and Metabolism 09/2009; 2(2):103-109. DOI:10.1007/s12349-009-0055-2
[Show abstract][Hide abstract] ABSTRACT: The aim of this study was to observe the microcirculation characteristics of the human interdental papilla in healthy patients in vivo. Twenty healthy patients were examined. Capillaroscopy was used to investigate the characteristics of microcirculation of the human periodontal mucosa. Visibility, course, tortuosity, as well as the average caliber of the capillary loops and the number of visible capillary loops per square millimeter were evaluated for each patient. The investigation of gingival mucosa revealed capillary loops with a course both parallel and perpendicular to the surface. Our study has pointed out that capillaroscopy is a reliable method to study periodontal microcirculation in vivo. This method could be applied to the study of microcirculation in periodontal diseases. Future studies might evaluate whether microcirculation in that area is compromised or not during systemic pathologies involving peripheral microcirculation alterations.
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