Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid.

Pfizer Global Research & Development, Michigan Laboratories, Ann Arbor, 48105, USA.
Bioorganic & Medicinal Chemistry Letters (Impact Factor: 2.33). 07/2005; 15(11):2812-8. DOI: 10.1016/j.bmcl.2005.03.106
Source: PubMed

ABSTRACT A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.

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