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Oktay K. Further evidence on the safety and success of ovarian stimulation with letrozole and tamoxifen in breast cancer patients undergoing in vitro fertilization to cryopreserve their embryos for fertility preservation. J Clin Oncol. 2005 Jun 1;23(16):3858-9

Journal of Clinical Oncology (Impact Factor: 18.43). 07/2005; 23(16):3858-9. DOI: 10.1200/JCO.2005.04.011
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    • "Evidently, in that case IVM has to be performed prior to fertilisation of the oocytes. Employing tamoxifen or letrozole based stimulation regimes may be used in the case of hormone sensitive tumors (see previous paragraph) (Oktay et al., 2005a, 2005b; Sonmezer & Oktay, 2006). Oktay et al. (2005b) has shown that in cancer patients who had been stimulated with this compound, recurrence rates were not elevated compared to cancer patients who had not been receiving any ovarian stimulation. "
    Topics in Cancer Survivorship, 01/2012; , ISBN: 978-953-307-894-6
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    • "L'e ´ quipe d'Oktay traite indiffé remment les patientes RHÀ ou RH+. La principale retenue concernant la stimulation vient des e ´ ventuels risques tumoraux lié s a ` l'e ´ lé vation de l'estradiolé mie, même si celle-ci est de courte duré e. Pour en limiter les e ´ ventuelles consé quences, Oktay et al. pré conisent le recours a ` un antiestrogè ne, le tamoxifè ne ou a ` un antiaromatase, le lé trozole, pendant la stimulation [17] [18]. Dans le même esprit, le recours aux antagonistes est pré fé ré a ` l'usage des agonistes, ces derniers pouvant par contre servir au dé clenchement pour limiter les risques d'hyperstimulation ovarienne [4] [19]. "
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    ABSTRACT: Breast cancer affects 6300 new patients per year under age 40 per year in France. The new adjuvant chemotherapy protocols have significantly improved the prognosis of these young women who may wish to conceive later. Embryo cryopreservation is the best way to preserve fertility, providing 25 to 35% chance of pregnancy. Oocyte freezing may be an alternative for single patients. This review will focus on: (1) ovarian toxicity of new adjuvant chemotherapy protocols, (2) the place of embryo or oocyte cryopreservation in fertility preservation techniques, (3) indications and protocols.
    Gynécologie Obstétrique & Fertilité 08/2011; 39(9):501-3. DOI:10.1016/j.gyobfe.2011.07.011 · 0.58 Impact Factor
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    ABSTRACT: Advances in the diagnosis and successful treatment of childhood, adolescent, and adult cancers have allowed many young women to lead healthy lives after overcoming their disease. However, life-saving cancer treatment often impairs fertility. Chemotherapy and/or radiation may irreversibly damage the reproductive system. The maturing field of assisted conception, and specifically cryopreservation, has created a unique partnership between oncologists and fertility specialists. Improving assisted conception success and fertility sparing strategies provide options for young women who would like to have children of their own after cancer treatment. This review article focuses on the current practices and developing opportunities for women who wish to preserve their fertility when faced with gonadotoxic cancer treatment.
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