There have been many cases of multiple malignant neoplasms involving the female genital tract reported, but involvement by epithelial and hematologic malignancy is extremely rare.
A 52-year-old woman, who was followed for stage 0 chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), had developed invasive squamous cell carcinoma of the uterine cervix. Microscopic examination of the hysterectomy specimen disclosed invasive squamous cell carcinoma in the cervix and monotonous populations of small lymphoid cells with proliferation centers, which are consistent with CLL/SLL, in the cervix as well as parametrium. Thirty months after the initial diagnosis of CLL/SLL, the patient died with systemic dissemination of squamous cell carcinoma, but the CLL/SLL remained a local disease.
The clinical course of squamous cell carcinoma in this case appeared to be aggressive, but it was unclear whether the outcome was associated with an altered immune status due to the presence of concurrent CLL/SLL.
"CLL seems to favor the onset of synchronous or metachronous epithelial cancers. A review of the literature showed that in a population of 10,823 patients with CLL, 9% developed a second synchronous or metachronous cancer . The association of CLL and squamous cell carcinomas of the upper aerodigestive tract (UADT) is not exceptional. "
[Show abstract][Hide abstract] ABSTRACT: INTRODUCTION: The association of squamous cell carcinoma of the larynx and chronic lymphocytic leukemia (CLL) is exceptional. We report an observation of this association and present the therapeutic problems as well as the effects on prognosis. OBSERVATION: Direct laryngoscopy showed a tumor of the right hemilarynx, with the biopsy concluding in moderately differentiated keratinizing squamous cell carcinoma. The patient had a total laryngectomy, with bilateral lymph node evidement. The anatomopathological examination of the operative specimen demonstrated infiltration of the larynx and squamous cell carcinoma adenopathies and CLL. It was decided to monitor the chronic lymphoid leukemia, classified as Binet stage B. The synchronous or metachronous onset of a second cancer in a patient with CLL is more frequent than in the general population. The synchronous association of squamous cell carcinoma of the larynx and CLL has been described only rarely. The therapeutic strategy should focus first on the cancer with the shortest survival rate. The prognosis is more negative in an association of cervicofacial squamous cell carcinoma and leukemia than in a single cervicofacial cancer.
European Annals of Otorhinolaryngology, Head and Neck Diseases 09/2010; 127(4):153-5. DOI:10.1016/j.anorl.2010.04.003 · 0.82 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: CD5 expression is considered a key marker for the diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). We report an unusual case of CD5-negative (CD5−) SLL with a concurrent CD5-positive (CD5+) adenocarcinoma of unknown primary involving the same lymph node. An 83-year-old woman with a history of CD5− B cell lymphoma diagnosed on a core biopsy of a cervical lymph node presented with jaundice and was found to have a 2.5-cm pancreatic mass. A fine needle aspiration of the mass revealed a CD5− monotypic B cell population. A subsequent excisional biopsy of a cervical lymph node showed morphologic findings typical for SLL, including the presence of multiple proliferation centers. However, the neoplastic lymphocytes were negative for CD5 by both flow cytometric analysis and immunohistochemistry. Interestingly, multifocal metastatic adenocarcinoma was identified and was positive for CD5. Lack of CD5 expression often leads to the exclusion of CLL/SLL, particularly in small biopsy samples. However, rare cases of CD5− CLL/SLL have been reported. In addition, CD5 is not an exclusive marker for lymphoid cells; its expression has been observed in several non-hematopoietic neoplasms. This report briefly reviewed and discussed CD5− CLL/SLL and CD5+ carcinoma reported in the literature.
[Show abstract][Hide abstract] ABSTRACT: The constant monitoring of large, medium and small power transformers for purposes of assessing their health, operating condition while maximizing personnel resources and preserving capital is often a topic of spirited discussions at both national and international conferences. Further, the considerations of transformers being out of service for extended periods of time due to conditions that, with the proper diagnostic monitoring equipment could have preemptively detected, diagnosed and prevented catastrophic equipment failure is of prime importance in today's economic conditions. These operating conditions are becoming more serious in several locations around the world. A recent case study of PD monitoring done at the Riband substation in India is discussed here in the sequel. Additional transformers tested in India for PGCIL (Ballabgarh) and NTPC (Noida, Delhi) in 1999 will be presented using the FDD-EPT system. Demonstrations of the FDD-EPT (fault diagnostic device for electrical power transformers) system on transformers for BHEL, MP and Tata Power in Mumbai also provided encouraging results. This will further illustrate the efficacy of this system.
Electrical Insulation, 2004. Conference Record of the 2004 IEEE International Symposium on; 10/2004
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