"Following a one-week acclimation period during which animals were allowed to adjust to the new housing conditions, male and female adolescent subjects (Andreollo et al., 2012; Kwekel et al., 2010; Quinn, 2005), now aged 6 weeks, were randomly assigned to either a control (vehicle only) or experimental group (BPA exposed). BPA (N99% purity grade) was obtained from Sigma-Aldrich Corp (St. "
"These observations are supported by human studies, demonstrating the 'programming' effects of stress in early life on the HPA axis and the brain (Barker, 1991), and further presented in adult patients suffering from major depressive disorders who had experienced early life stress, and show persistent hyper activity of the HPA axis and of the autonomous nervous system, as well as increased sensitivity of these systems to stress (Heim et al., 2000a,b). Carefully considering the complex translation of rat to human lifespan (Quinn, 2005), together with the vigorous maturation which the brain undergoes during the transition period between childhood to adulthood (Sowell et al., 1999; Rubinow and Juraska, 2009; Avital et al., 2011), it seems that the available data supports the hypothesis that adolescence is a 'stress-sensitive' period (Andersen and Teicher, 2008; Leussis and Andersen, 2008). However, it has been also suggested that the development of emotionality and its underlying neural systems, remain highly plastic during the juvenile and pubescence periods (Holmes et al., 2005; Holder and Blaustein, 2014). "
"To compare CoQ status between ageing pigs, mice, and worms and to translate these results to the human situation, we estimated the corresponding human ages of these species by using our own data and data from literature      (Table 2). So, a rough comparison between humans, pigs, mice, and worms becomes possible. "
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