Article

Effect of chemical enhancers on the in vitro percutaneous absorption of sumatriptan succinate.

Departamento de Fisiología, Farmacología y Toxicología, Facultad de Ciencias Experimentales y de la Salud, Universidad Cardenal Herrera-CEU, Moncada, Spain.
European Journal of Pharmaceutics and Biopharmaceutics (impact factor: 4.27). 10/2005; 61(1-2):50-5. DOI:10.1016/j.ejpb.2005.02.014 pp.50-5
Source: PubMed

ABSTRACT The effects of percutaneous enhancers on the transdermal absorption of sumatriptan succinate were investigated by in vitro permeation studies. Pretreatment of porcine skin with ethanol (vehicle), polyethylene glycol 600, Span 20, oleic acid, R-(+)-limonene, alpha-bisabolol and 1,8-cineole (at 5% in ethanol, w/w) produced in all cases an increase in the flux of sumatriptan. The amount of sumatriptan retained in the skin was also determined. Ethanol has showed a low but significant increment on the drug transdermal flux. Treatment of the skin with alpha-bisabolol shows the same enhancer effect than ethanol. Span 20, oleic acid, and polyethylene glycol 600 have shown a moderate enhancing activity on transdermal flux of sumatriptan. R-(+)-limonene showed the greatest ability to enhance the flux of sumatriptan.

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Keywords

cases
 
drug transdermal flux
 
enhancer effect
 
Ethanol
 
greatest ability
 
moderate
 
percutaneous enhancers
 
polyethylene glycol 600
 
porcine skin
 
Pretreatment
 
R-(+)-limonene
 
significant increment
 
sumatriptan
 
sumatriptan succinate
 
transdermal absorption
 
transdermal flux
 
vitro permeation studies