Article

New pregnane glycosides from Caralluma dalzielii.

Dipartimento di Chimica Bioorganica e Biofarmacia, Università di Pisa, 56126 Pisa, Italy.
Steroids (Impact Factor: 2.8). 09/2005; 70(9):573-85. DOI: 10.1016/j.steroids.2005.03.013
Source: PubMed

ABSTRACT Twenty-seven new pregnane glycosides were isolated from the whole plant of Caralluma dalzielii, and their structures elucidated from extensive 2D NMR analysis as well as ESI-MS experiments. All isolated compounds were tested for their antiproliferative activity on J774.A1, HEK-293, and WEHI-164 cell lines. Moderate to high potency of cytotoxicities were found in almost all tested compounds, confirming the significant cytotoxic activity of pregnane glycosides.

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