Article

Calcium deficiency cannot induce obesity in rats.

Département d'anatomie et physiologie, Centre de recherche sur le métabolisme énergétique (CREME), Université Laval, Québec, Canada, G1K 7P4.
Physiology & Behavior (impact factor: 2.87). 07/2005; 85(3):259-64. DOI:10.1016/j.physbeh.2005.03.026 pp.259-64
Source: PubMed

ABSTRACT If intake of a required nutrient--here calcium--affects body weight, the effect must be mediated by a change in the body weight set-point. Thus, the controversial 'anti-obesity' influence of high calcium intake should decrease the body weight set-point. Diets differing in calcium content were assigned to three groups of rats. The effects of the diets on body weight, BMI, fat content, plasma calcium, body weight set-point, food intake, and preference for various calcium solutions were measured after 6 weeks of calcium deprivation or supplementation, and again after a further 6 weeks of recovery on a regular diet. After 6 weeks, the low-calcium diet had induced calcium deficiency but had failed to raise the body weight set-point. Nor had it produced obesity or fat accumulation. After 6 weeks of recovery, body weight and fat content were no higher in calcium-deprived rats than in the control or supplemented rats. In this experiment, low-calcium intake failed to cause obesity and did not raise the body weight set-point. The results indicate that calcium intake probably does not affect body weight.

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Keywords

6 weeks
 
BMI
 
body weight
 
body weight set-point
 
calcium content
 
calcium intake
 
calcium-deprived rats
 
cause obesity
 
controversial 'anti-obesity' influence
 
Diets
 
fat content
 
food intake
 
low-calcium diet
 
low-calcium intake
 
obesity
 
plasma calcium
 
regular diet
 
supplementation
 
supplemented rats
 
various calcium solutions