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Vitamin E as a treatment for ulcerative dermatitis in C57BL/6 mice and strains with a C57BL/6 background.

Division of Laboratory Animal Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, California 90095-1718, USA.
Contemporary topics in laboratory animal science / American Association for Laboratory Animal Science (Impact Factor: 0.82). 06/2005; 44(3):18-21.
Source: PubMed

ABSTRACT In this study, we fed a standard NIH-31 diet fortified with vitamin E to C57BL/6 mice and strains of mice with a C57BL/6 background that had spontaneously developed ulcerative dermatitis (UD). In addition to the therapeutic response to increased levels of vitamin E, we also defined the occurrence of UD within our facility in terms of age, sex, coat color, and lesion location on the body. Mice with spontaneous UD were fed a vitamin E-fortified diet (3000 IU/kg) for a period of 8 weeks and entered the study without regard to vendor source, age, sex, coat color, or the site or number of UD lesions. We found that lesions occurred most commonly on the dorsal cervical and scapular regions and spared the ventral abdomen and thorax. No sex or coat color predilection was noted for the development of UD, however males were older than females at the time of lesion development. Of 71 mice, 32 (45%) had complete lesion re-epithelialization with hair regrowth. Complete lesion repair was not influenced by sex, age, or coat color. The average time to complete lesion repair ranged from 2 to 5 weeks, and there was no correlation with sex or coat color. The positive response to vitamin E suggests that protection from oxidative injury may play a role in the resolution of UD lesions and offers veterinarians and investigators a new treatment option with ease of compliance.

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    • "Trp53 heterozygous mice had a significantly lower frequency of severe disease, but it appeared significantly earlier than in Trp53 normal mice, indicating a link between the appearance of this disease and the level of Trp53 function (Mitchel et al. 2007). The link between chronic ulcerative dermatitis and oxidative stress (Lawson et al. 2005) suggests that in animals with fully or partially functional Trp53, radiation may act on ulcerative dermatitis in a manner similar to its action in radiation carcinogenesis , where a low dose induces an adaptive response that protects against the carcinogenic effects of an oxidative stress from a subsequent radiation exposure (Mitchel et al. 1999, 2004). "
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    • "Previously, treatment of established ulcerative dermatitis by putting mice on a vitamin E diet showed some success in resolution in the ulcerative dermatitis. Lawson et al. (2005) suggested that a diet fortified with vitamin E lessens the severity of ulcerative dermatitis, possibly due to its antioxidant nature. It may be that a high concentration of vitamin E in the diet at a young age is more harmful than helpful. "
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