Article

Effect of okadaic acid on integrins and structural proteins in BE(2)-M17 cells.

Microbiology and Biotoxins Area, ANFACO-CECOPESCA, Campus Univ Vigo, 36310 Pontevedra, Spain.
Archive für Toxikologie (impact factor: 4.67). 11/2005; 79(10):582-6. DOI:10.1007/s00204-005-0679-z pp.582-6
Source: PubMed

ABSTRACT Okadaic acid (OA), an algal toxin, is known to induce Diarrhetic Shellfish Poisoning and apoptosis in a variety of cell lines. One of the main targets of OA is the actin cytoskeleton which can be modulated by integrins and other structural proteins. In this paper we studied the role of these proteins and skeletal structures on OA-induced apoptosis in neuroblastoma cells. Results show that beta1 integrin and vinculin are down-regulated when cells were exposed to OA. We observed an interaction between talin and beta1 integrin that is impaired in OA treated cells.

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Keywords

actin cytoskeleton
 
algal toxin
 
beta1 integrin
 
cell lines
 
induce Diarrhetic Shellfish Poisoning
 
integrins
 
main targets
 
neuroblastoma cells
 
Okadaic acid
 
proteins
 
skeletal structures
 
structural proteins
 
vinculin