Article

Prevalence and correlates of paediatric asthma and wheezing in a largely rural USA population

Department of Family and Community Medicine and Rural and Community Health Center, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA.
Journal of Paediatrics and Child Health (Impact Factor: 1.19). 05/2004; 40(4):189-94. DOI: 10.1111/j.1440-1754.2004.00335.x
Source: PubMed

ABSTRACT The prevalence of asthma among children has been increasing in the United States and it is estimated that there are approximately 5 million children with asthma. This cross-sectional survey sought to estimate the prevalence of asthma and asthma symptoms and potential risk factors among children aged 16 and younger, in a largely rural population in the USA.
This study was a telephone survey of 1500 households in the South Plains/Panhandle region of Texas. Parents of children were interviewed with a response rate of 64%. Having been diagnosed with asthma by a physician and a report of wheezing in the last 12 months were used as dependent variables in multivariate logistic regressions with several sociodemographic and environmental factors as potential confounders.
The age-adjusted prevalence of asthma and wheezing among children were approximately 15 and 18%, respectively. The prevalence of asthma was highest (20%) among children aged 11-16 (P < 0.001). Living in urban areas was associated significantly with asthma and wheezing. Non-Hispanic blacks reported significantly increased odds of asthma in their children (adjusted odds ratio (OR) = 2.04, 95%CI 1.02-4.08), whereas Mexican-Americans reported significantly reduced odds of asthma (adjusted OR = 0.48, 95%CI 0.29-0.78) and wheezing (adjusted OR = 0.58, 95%CI 0.37-0.89) in their children. The odds of asthma (adjusted OR = 1.78, 95%CI 1.09-2.92) and wheezing (adjusted OR = 2.45, 95%CI 1.52-3.95) was highest among children in the highest body mass index quartile. No significant association with pet ownership and exposure to second-hand smoke with asthma and wheezing was observed in this study.
Urban residence, non-Hispanic black and Mexican-American race/ethnicity, and being overweight were significantly associated with the increased risk of asthma and/or wheezing.

0 Followers
 · 
119 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: O sevoflurano é um agente anestésico inalatório largamente utilizado e não há, até o momento, estudos descrevendo seus efeitos sobre vias aéreas cronicamente inflamadas e remodeladas, como se observa na asma. O presente estudo objetivou definir os efeitos respiratórios do sevoflurano em um modelo de asma alérgica crônica. Para tal, 36 camundongos BALB/c foram aleatoriamente divididos em 4 grupos. Nos grupos OVA, os animais foram sensibilizados e expostos a repetidos desafios com ovalbumina. Nos grupos SAL, solução salina foi administrada observando-se o mesmo protocolo. Vinte e quatro horas após o ultimo desafio, os animais foram anestesiados com pentobarbital sódico (PENTO, 20 mg/kg intraperitoneal) ou sevoflurano (SEVO, 1 concentração alveolar mínima). A elastância estática (Est) e as pressões necessárias para vencer os componentes resistivo (DP1) e viscoelástico/inomogêneo (DP2) do pulmão foram analisadas através do método da oclusão ao final da inspiração. Os pulmões foram fixados e corados para análise histológica. Os animais do grupo OVASEVO apresentaram valores menores para DP1 (38%), DP2 (24%) e Est (22%) do que os do grupo OVAPENTO. A histologia revelou redução do índice de constrição (16%) e menores áreas de colapso alveolar (25%) no grupo OVASEVO do que no OVAPENTO. Além disso, DP1 mostrou-se diminuído (35%) e os diâmetros das vias aéreas aumentados (12%) nos animais do grupo SALSEVO comparativamente àqueles do grupo SALPENTO. Em conclusão, na asma alérgica crônica o sevoflurano atuou tanto nas vias aéreas centrais quanto na periferia do pulmão, promovendo uma diminuição nas pressões resistiva, viscoelástica e/ou inomogênea e na elastância estática pulmonares.
    11/2006, Degree: MSc, Supervisor: Patricia Rieken MAcêdo Rocco
  • Source
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective: To investigate the role of the Mediterranean diet and physical activity on the relation between living environment and childhood asthma. Methods: 1125 children (529 boys), 10 to 12 years old were recruited either in an urban environment (Athens, n = 700) or rural environment (n = 425) in Greece. A path analytic model was developed to assess the causal relation between urban environment and asthma prevalence (standardized ISAAC questionnaire), through the mediation of the Mediterranean diet (evaluated by the KIDMED food frequency questionnaire) and physical activity (evaluated by the PALQ physical activity questionnaire). Results: The proposed model had a very good fit (χ2/df ratio =1.05, RMSEA=0.007, 90% confidence interval: 0.01 to 0.046, p=0.97, CFI = 0.98). A significant total positive effect was found between urban environment and asthma symptoms (standardized beta= 0.09, p<0.001). Adherence to the Mediterranean diet was related negatively with asthma symptoms (standardized beta = -0.224, p<0.001). An inverse mediating effect of the Mediterranean diet was observed for the urban environment - asthma relation (standardized beta=-0.029, p<0.001) while physical activity had no significant contribution (p=0.62), adjusted for several confounders. Conclusions: The Mediterranean diet may protect against the harmful effect of urban environment on childhood asthma.
    Endocrine Metabolic & Immune Disorders - Drug Targets(Formerly Current Drug Targets - Immune Endocrine & Metabolic Disorders) 08/2014; 14(3). DOI:10.2174/1871530314666140826102514

Full-text

Download
57 Downloads
Available from
May 22, 2014