Article

Exposure to bisphenol A is associated with recurrent miscarriage

Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya, Japan.
Human Reproduction (Impact Factor: 4.59). 09/2005; 20(8):2325-9. DOI: 10.1093/humrep/deh888
Source: PubMed

ABSTRACT Little is known about the influence of high exposure to bisphenol A on recurrent miscarriage and immunoendocrine abnormalities.
Serum bisphenol A, antiphospholipid antibodies (aPLs), antinuclear antibodies (ANAs), natural killer cell (NK) activity, prolactin, progesterone, thyroid-stimulating hormone (TSH) and free T4 were examined in 45 patients with a history of three or more (3-11) consecutive first-trimester miscarriages and 32 healthy women with no history of live birth and infertility. Subsequent pregnancy outcome and embryonic karyotype of abortuses were examined prospectively.
The mean+/-SD values for bisphenol A in patients were 2.59+/-5.23 ng/ml, significantly higher than the 0.77+/-0.38 ng/ml found for control women (P=0.024). High exposure to bisphenol A was associated with the presence of ANAs but not hypothyroidism, hyperprolactinaemia, luteal phase defects, NK cell activity or aPLs. A high level of bisphenol A in itself did not predict subsequent miscarriage.
Exposure to bisphenol A is associated with recurrent miscarriage.

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    • "Indeed, elevated placental hCG levels have been linked to pregnancy complications, such as preterm birth [60], fetal growth restriction (FGR) [61], and preeclampsia [62]. Importantly , high placental concentrations of BPA are associated with preeclampsia [4], and elevated plasma levels of BPA in pregnant women are linked to recurrent miscarriages [5] as well as FGR [6]. Therefore, BPA-induced increases in placental hCG expression and secretion may contribute to the pathogenesis of these pregnancy complications. "
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    ABSTRACT: This study examined the effect of bisphenol A (BPA) on human placental gene expression using primary trophoblast cells as an in vitro model system. Trophoblast cells were isolated from human placentas at term, cultured and then exposed to environmentally relevant concentrations of BPA (0.1-2μg/ml) for up to 24h, after which levels of 11β-HSD2 mRNA, protein and activity were determined by standard radiometric conversion assay, western blotting, and qRT-PCR, respectively. The mRNA levels of several other prominent placental hormones/factors were also assessed by qRT-PCR. BPA dramatically increased levels of 11β-HSD2 activity, protein and mRNA in a time- and concentration-dependent manner (>4-fold). BPA also augmented aromatase, glucose transporter-1, CRH, and hCG mRNA levels while reducing the level of leptin mRNA. These findings demonstrate that BPA severely disrupts human placental gene expression in vitro, which suggests that exposure to BPA may contribute to altered placental function and consequent pregnancy complications. Copyright © 2015. Published by Elsevier Inc.
    Reproductive Toxicology 03/2015; 53. DOI:10.1016/j.reprotox.2015.03.001 · 2.77 Impact Factor
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    • "It is therefore possible that failure or deficiencies in trophoblast proliferation or differentiation may compromise placental development, since there have been studies showing elevated apoptosis in placenta from pregnancies complicated by IUGR [31] and preeclampsia [32]. Sugiura-Ogasawara et al. [33] reported an association between serum BPA levels and recurrent miscarriage. Blood BPA levels of patients with a history of three or more consecutive first-trimester miscarriages were approximately three times higher than those of controls. "
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    Placenta 09/2014; DOI:10.1016/j.placenta.2014.08.091 · 3.29 Impact Factor
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