Advanced paternal age associated with an elevated risk for schizophrenia in offspring in a Japanese population.
ABSTRACT Advanced paternal age at birth as a risk for schizophrenia in the adult offspring has been reported in previous studies exclusively conducted in Western countries and Israel. The question has arisen whether this finding could be replicated in countries with socially and culturally different attitudes toward marriage, including factors such as age at marriage. To address this question, we conducted a case-control study of a Japanese population.
The subjects were representative inpatients with a DSM-IV diagnosis of schizophrenia. Unrelated healthy volunteers were recruited as control subjects. This study was conducted as one of a series of the projects by use of "The Mother and Child Health Handbooks (MCHHs)," from which information on parental characteristics around the time of birth, including parental ages at birth, had been extracted and recorded on computer.
Ninety-nine subjects with schizophrenia and 381 healthy control subjects enrolled for the study. Advanced paternal, but not maternal, age was associated with an elevated risk for schizophrenia. Reproducibility of the association across different cultures is suggestive of a causal link.
- SourceAvailable from: Samaher Alfaraj[Show abstract] [Hide abstract]
ABSTRACT: Objective To evaluate the effect of paternal age on in-vitro fertilization (IVF) outcomes. Design Retrospective cohort study. Setting Reproductive Endocrinology and Infertility Unit. Patients The study included 451 couples undergoing their first IVF cycle. Main outcome measures Effect of advancing paternal age on: semen parameters; IVF cycle-related factors e.g., number of oocyte retrieved, fertilization rate, high quality embryo rate; and IVF outcome i.e., pregnancy rate. Results The mean paternal age in our study was 36.3 years (range: 24–76 years). Approximately half of the study couples (51.9%) had secondary infertility with anovulation being the major cause. We found no significant correlations between the advancing paternal age and the semen parameters – sperm volume (p = 0.28), sperm concentration (p = 0.47), or sperm motility (p = 0.91). IVF cycle-related factors did not significantly differ for advancing paternal age groups – number of oocyte retrieved (p = 0.52), number of embryos fertilized (p = 0.14), fertilization rate (p = 0.94), or the high quality embryo rate (p = 0.84). Likewise, we found no significant association between the advancing paternal age and the positive IVF outcome i.e., the positive serum pregnancy test (p = 0.64). Conclusion Advancing paternal age does not affect the IVF outcomes in a Saudi population.Middle East Fertility Society Journal 09/2014;
- Iatreia 08/2013; 26(3).
- Annals of Physical and Rehabilitation Medicine 10/2011; 54.