Recollection of vivid memories after perirhinal region stimulation: Synchronization in the θ range of spatially distributed brain areas

Laboratoire de Neurophysiologie et de Neuropsychologie, INSERM EMI-U 9926, Faculté de Médecine, 27 Boulevard Jean Moulin, 13385 Marseille, France.
Neuropsychologia (Impact Factor: 3.3). 02/2005; 43(9):1329-37. DOI: 10.1016/j.neuropsychologia.2004.11.025
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Electrical stimulation of the temporal cortex in patients with epilepsy sometimes elicits experiential phenomena such as recollection of vivid memories. The neurophysiological substrate of such phenomena is poorly understood. Furthermore, the relation between the site of stimulation and the type of memory elicited has only recently started to be investigated. We investigated these issues in patient FGA who had intracerebral electrodes stereotaxically implanted in the right temporal lobe for investigation of drug-resistant epilepsy. We report the results of electrical stimulations of the perirhinal region. Two stimulations elicited experiential phenomena consisting of visual memories that belonged to FGA's past, but which were not related to any particular episode. These visual memories consisted of objects or of details of objects. These two stimulations were contrasted with other stimulations in the same subhippocampal region. Cross-correlation analysis of the depth-EEG signals filtered in frequency sub-bands revealed that experiential phenomena occurred only when the various brain structures involved in the after-discharge were synchronized in the theta range. These structures included the perirhinal region, the hippocampus, other limbic structures as well as a primary visual area. Our results suggest that recollection of vivid memory after electric stimulation of the cortex may rely on wide networks of brain areas that transiently synchronize. These results also highlight the role of the perirhinal region in human memory. Experiential phenomena are rarely obtained after brain stimulation. Replication of these results is thus required due to the small number of observations reported.

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    • "(Barbeau et al., 2005; Bartolomei et al., 2012 "

    Frontiers in Psychology 04/2014; 5:255. DOI:10.3389/fpsyg.2014.00255 · 2.80 Impact Factor
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    • "Rugg and Yonelinas (2003) reviewed evidence for the F/R distinction, and concluded that the findings are consistent with the notion that hippocampal activation is a correlate of recollection whereas familiarity depends on other structures in the anterior MTL region. A more specific suggestion was made by Barbeau et al. (2005) who implanted electrodes as part of the presurgical procedure in the right temporal lobe of a patient suffering from right temporal lobe epilepsy. Electrical stimulation delivered through contacts located just lateral to the perirhinal cortex evoked vivid visual perceptions of familiar scenes, although these 'memories' were apparently unrelated to any specific past event. "
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    Neuropsychologia 04/2014; 56(1). DOI:10.1016/j.neuropsychologia.2014.02.007 · 3.30 Impact Factor
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    • "); LSD Psychotherapy (Grof, 1980) Reports of high-voltage theta and slow-wave activity detected in the medial temporal regions of humans Freemon & Walter, 1970; Giaquinto, 1973; Salzarulo et al., 1975; Mann et al., 1997; Yu et al., 1997; Bodizs et al., 2001; Cantero et al., 2003 Bickford et al., 1956; Delgado et al., 1956; Kellaway, 1956; Liberson, 1956; Wieser, 2004; Bragin et al., 2005; Barbeau et al., 2005 Sem-Jacobsen et al., 1955, 1956; Monroe, 1956; Kendrick & Gibbs, 1957; Delgado & Hamlin, 1960; Heath & Mickle, 1960; Heath & Walker, 1985; Sherwood, 1962; Heath & Leach, 1962; Hanley et al., 1972 Schwarz et al., 1956b; Monroe et al., 1957 Table 1 Summary of the key texts cited in this paper the case for dreamlike phenomena. For example, dissociation and depersonalization can be seen as compatible to a large extent with ego dissolution. "
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