Attention deficit hyperactivity disorder and borderline personality disorder

Department of Psychiatry and Psychotherapy, University of Duisburg-Essen - Rhine Clinics Essen - Virchowstrasse 174, 45147 Essen, Germany.
Progress in Neuro-Psychopharmacology and Biological Psychiatry (Impact Factor: 4.03). 08/2005; 29(6):865-77. DOI: 10.1016/j.pnpbp.2005.04.033
Source: PubMed

ABSTRACT To evaluate the association between attention deficit hyperactivity disorder (ADHD) and the diagnosis of borderline personality disorder (BPD) in adulthood, a systematic review of published follow-up data, mainly from observational studies was done. Electronic databases Medline, PsychInfo and PSYNDEXplus were searched from their earliest entries. All studies suggested significant relationships between ADHD and BPD. From a phenomenological point of view there seem to exist some similarities between these two disorders: deficits in affect regulation and impulse control, substance abuse, low self esteem and disturbed interpersonal relationship are common in both conditions. From a neuropsychological point of view dissociation in BPD might be regarded as a special form of behavioral inhibition and sustained attention comparable to ADHD. Possible therapeutic strategies of comorbid ADHD and BPD are discussed.

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    ABSTRACT: Inferior frontal white matter circuits are likely to be relevant to dysfunctional affect regulation, aggression, dissociative symptoms, neuropsychological functioning and psychopathology in women with borderline personality disorder (BPD) and comorbid attention-deficit hyperactivity disorder (ADHD). 20 women with BPD and comorbid ADHD and 20 healthy women were investigated, and groups were matched for age, education and premorbid intelligence. Mean diffusivity and fractional anisotropy were measured bilaterally in the inferior frontal white matter by diffusion tensor imaging (DTI). Conflict resolution was assessed by the Attention Network Test, sustained vigilance by the Degraded-Stimulus Continuous Performance Test. Among women with BPD and comorbid ADHD, increased mean diffusivity in inferior frontal white matter was associated with higher levels of dysfunctional affect regulation, anger-hostility, dissociative symptoms, and general psychopathology (p<.05, uncorrected). Poor conflict resolution during the attention task was positively associated with anger-hostility, psychopathology, dissociation and the number of ADHD-symptoms, but not related to DTI variables. Both groups did not differ significantly with respect to DTI variables or neuropsychological performance. In the BPD group, a lifetime history of major depression or a current eating disorder were associated with impaired inferior frontal white matter integrity, while a history of sexual abuse or a current posttraumatic stress disorder were not. Inferior frontal white matter microstructural abnormalities may be linked to key aspects of psychopathology in women with BPD and comorbid ADHD and add to alterations in orbitofrontal and limbic areas. The relationship between neuropsychological functioning and white matter structure remains unclear.
    NeuroImage 05/2007; 35(2):738-47. DOI:10.1016/j.neuroimage.2006.12.007 · 6.13 Impact Factor
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    ABSTRACT: Introduction: This research was down to compare Relationship with spouse and restriction of role between Mothers with ADHD sons and the normal ones. Materials and Methods: The research is a causal-comparing study and the statistical universe was all mothers of 5 to 12 years old sons with ADHD who referred to child psychiatry clinics (I bn-e-Sina and Dr Sheikh Hospitals) and all Mothers of normal son (5 to 12 years old) were selected in primary and pre-primary school at 4th educational area of Mashhad city, north-eastern part of Iran. Fifty mothers with ADHD children by at reached sampling and 80 Mothers with normal children were selected by cluster sampling. Parenting Stress Index (PSI) was used and data analyzed by descriptive and analytic statistical methods such as T-test in independent groups. Results: Results showed that there was a significant difference between relationship with spouse in mothers of ADHD children and mother of normal children (p<0.000). There was a significant difference between restriction of role in Mothers of ADHD children and mother of normal children (p<0.000) Conclusion: Mothers with ADHD children had more restriction of role compared with mothers of normal children and they also had more problems in their relationship with spouse which it is realized by parenting stress index.
    Procedia - Social and Behavioral Sciences 12/2012; 46:750-753. DOI:10.1016/j.sbspro.2012.05.192
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    ABSTRACT: Objective: Working memory is the ability of maintaining and manipulating the required information for operating generalization in future. The aim of the present research is to investigate the effectiveness of neurofeedback therapy on the working memory in children with ADHD. Method: 24 children with ADHD who had the required standards to participate in the study were selected by accessible sampling and put randomly in an experimental group or a control group. The experimental group attended 20 sessions of neurofeedback instruction for 2 months. The individuals from both groups (experimental or control) were assessed and compared by giving SWM test in two stages of pre-test and post-test. The obtained results were analyzed by the statistic method of covariance analysis. Results: Neurofeedback instruction is able to recover the working memory of children with ADHD. Conclusion: Neurofeedback instruction can be used as an intervening method for working memory recovery in children with ADHD.