Prevalence and Socioeconomic Impact of Upper Gastrointestinal Disorders in the United States: Results of the US Upper Gastrointestinal Study

Mayo Clinic College of Medicine, Center for Enteric Neurosciences and Translational Epidemiological Research, Rochester, MN, USA.
Clinical Gastroenterology and Hepatology (Impact Factor: 6.53). 06/2005; 3(6):543-52. DOI: 10.1016/S1542-3565(05)00153-9
Source: PubMed

ABSTRACT This study examined the prevalence of upper gastrointestinal (GI) symptoms and symptom groupings and determined impact on disability days in a nationally representative US sample.
A telephone survey of 21,128 adults was conducted including questions about the presence of upper GI symptoms during the past 3 months. Respondents were categorized as symptomatic (ie, reported GI symptoms once per month) or asymptomatic. The survey included questions about missed work, leisure activity, or household activity days. Symptom groupings were identified by using factor analysis, and cluster analysis was used to assign respondents into distinct groups on the basis of these symptom groupings.
The prevalence of an average of 1 or more upper GI symptoms during the past 3 months was 44.9%. The most common symptoms experienced during the past 3 months were early satiety, heartburn, and postprandial fullness. Factor analysis identified 4 symptom groupings: (1) heartburn/regurgitation; (2) nausea/vomiting; (3) bloating/abdominal pain; and (4) early satiety/loss of appetite. Five respondent clusters were identified; the largest clusters were primarily early satiety/fullness (44%) and gastroesophageal reflux disease-like symptoms (28%). Two small clusters reflected nausea and vomiting (7%) and a heterogeneous symptom profile (4%). Symptomatic respondents reported significantly more missed work, leisure, and household activity days than asymptomatic respondents (all P < .0001).
Factor analysis separated GI symptoms into groupings reflecting gastroesophageal reflux disease and dyspepsia: early satiety, postprandial fullness, and loss of appetite; bloating and abdominal pain/discomfort; and nausea and vomiting. These upper GI symptoms were associated with significant loss of work and activity days.

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    • "The term ''dyspepsia'' is derived from the term for ''bad digestion'' in Greek. The relationship between meals and dyspeptic symptoms is also critical, as evidenced by a large epidemiologic study in the United States [7] and a population-based study in Olmsted County, Minnesota [8]. The latter identified that meals evoked symptoms in 60% of those with dyspepsia. "
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    • "Reference Sample size reported Sample size Ն200 Response rate reported Response rate Ն50% Recall period reported Recall period Յ1 y At least weekly symptoms reported Ruth et al, 16 2005 No No Fujiwara et al, 62 2005 No Mohammed et al, 63 2005 No Mishima et al, 28 2005 No Moraes-Filho et al, 64 2005 No No Camilleri et al, 65 2005 No Rajendra and Alahuddin, 66 2004 No No Wong et al , 67 2004 No Fujimoto et al, 68 2003 No No No No Khoshbaten, 69 2003 No No No Nilsson et al, 70 2003 No Watanabe et al, 71 2003 No Cameron et al, 72 2002 No Conio et al, 73 2002 No No Louis et al, 74 2002 No No Agreus et al, 17 2001 No Avidan et al, 75 2001 "
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