Article

Serum and CSF vitamin A concentrations in idiopathic intracranial hypertension.

Neuro-ophthalmology Clinic, School of Public Health, Tehran University of Medical Sciences, Iran.
Neurology (impact factor: 8.31). 06/2005; 64(11):1893-6. DOI:10.1212/01.WNL.0000163556.31080.98 pp.1893-6
Source: PubMed

ABSTRACT Elevated serum retinol, CSF retinol, and serum retinol binding protein (RBP) levels have been found in some patients with idiopathic intracranial hypertension (IIH), but serum and CSF retinol levels have not been studied in matched serum and CSF samples in patients with IIH.
To determine whether serum and CSF vitamin A concentrations are associated with IIH.
The serum and CSF retinol concentrations were prospectively assessed in 20 patients with IIH and 20 control subjects.
CSF retinol concentration was higher in the patient group (median 575.91 nM) vs the control group (median 63.35 nM) (p < 0.05). There was no difference in serum retinol levels between control subjects (median 896.51 nM) and patients (median 1,002.62 nM) (p = 0.10). There was an association between higher vitamin A levels (> 250 nM) and IIH (p = 0.039). There was a correlation between CSF and serum retinol levels in patients (r = 0.82) and control subjects (r = 0.66).
Elevated CSF retinol concentration is associated with idiopathic intracranial hypertension (IIH), but serum retinol level is not associated with IIH.

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Keywords

20 control subjects
 
20 patients
 
concentrations
 
control group
 
control subjects
 
CSF retinol
 
CSF retinol concentration
 
CSF retinol concentrations
 
CSF retinol levels
 
CSF samples
 
Elevated CSF retinol concentration
 
Elevated serum retinol
 
higher vitamin
 
idiopathic intracranial hypertension
 
patient group
 
patients
 
RBP
 
serum retinol binding protein
 
serum retinol level
 
serum retinol levels
 

Abdolreza Tabassi