IL-2 and TNF-alpha promoter polymorphisms in patients with acute kidney graft rejection.

Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, 70-111 Szczecin, Powst Wlkp 72, Poland.
Transplantation Proceedings (Impact Factor: 0.95). 07/2005; 37(5):2041-3. DOI: 10.1016/j.transproceed.2005.03.091
Source: PubMed

ABSTRACT Proinflammatory cytokines have been implicated in the pathogenesis of acute kidney allograft rejection. The aim of the study was to examine the association between interleukin (IL)-2 -330 and tumor necrosis factor (TNF)-alpha -308 promoter polymorphisms and acute kidney allograft rejection.
The study included 72 patients with long-term stable graft function, and 57 diagnosed with acute kidney allograft rejection.
Patients with acute kidney allograft rejection showed a prevalence of subjects with TNF-alpha T2 allele (P < .05). The risk of acute kidney allograft rejection diagnosis was 2.5-fold greater among carriers of the T2 allele than those homozygous for T1T1 (OR 2.53, 95% CI 1.19 to 5.37, P < .05) There was no statistically significant difference in the distribution of IL-2 genotypes between patients with stable graft function and acute kidney allograft rejection.
The results suggest that TNF-alpha-308 promoter polymorphism is a risk factor for acute kidney allograft rejection.

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