Spontaneous resolution of hemophagocytic syndrome and disseminated intravascular coagulation associated with parvovirus B19 infection in a previously healthy child

Department of Pediatric Hematology, Gazi University Medical School, Ankara, Turkey.
Japanese journal of infectious diseases (Impact Factor: 1.16). 07/2005; 58(3):149-51.
Source: PubMed

ABSTRACT A 10-year-old male with a brain abscess developed pancytopenia, liver dysfunction, disseminated intravascular coagulation (DIC) and decrease of immunoglobulin A (IgA) level during postoperative antibiotic and anticonvulsant therapy. A bone marrow examination revealed hemophagocytosis. Real-time PCR revealed parvovirus B19 infection. The hemophagocytic syndrome resolved without specific treatment. To our knowledge, this is the first report of a spontaneous resolution of parvovirus B19-associated hemophagocytic syndrome and DIC.

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