Article

Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis.

Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Italy.
Journal of Natural Products (impact factor: 3.13). 07/2005; 68(6):853-7. DOI:10.1021/np050120q pp.853-7
Source: PubMed

ABSTRACT Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.

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Keywords

11 germacrane sesquiterpenes
 
Chemical investigation
 
chemical transformations
 
modified Mosher method
 
selective cytotoxic activity
 
spectroscopic techniques
 
stereostructures