ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5

Bioinformatics Program, Boston University, Boston, Massachusetts 02215, USA.
Proteins Structure Function and Bioinformatics (Impact Factor: 2.92). 08/2005; 60(2):207-13. DOI: 10.1002/prot.20559
Source: PubMed

ABSTRACT We present an evaluation of the results of our ZDOCK and RDOCK algorithms in Rounds 3, 4, and 5 of the protein docking challenge CAPRI. ZDOCK is a Fast Fourier Transform (FFT)-based, initial-stage rigid-body docking algorithm, and RDOCK is an energy minimization algorithm for refining and reranking ZDOCK results. Of the 9 targets for which we submitted predictions, we attained at least acceptable accuracy for 7, at least medium accuracy for 6, and high accuracy for 3. These results are evidence that ZDOCK in combination with RDOCK is capable of making accurate predictions on a diverse set of protein complexes.

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